Results 61 to 70 of about 59,334 (307)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Surrogate modeling with sequential design for design and analysis of electronic systems

open access: yes, 2017
The growing computational demands of modern engineering simulations as used frequently in fields ranging from computational fluid dynamics to electromagnetics, requires methodologies to be able to perform evaluation intensive tasks.
Dhaene, Tom   +7 more
core   +1 more source

A surrogate FRAX model for Mongolia

open access: yesArchives of Osteoporosis
Abstract Summary A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia.
Jaalkhorol, M.   +8 more
openaire   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Surrogate Modeling for Liquid–Liquid Equilibria Using a Parameterization of the Binodal Curve

open access: yes, 2019
Computational effort and convergence problems can pose serious challenges when employing advanced thermodynamic models in process simulation and optimization.
Sundmacher, K. ; https://orcid.org/   +11 more
core   +2 more sources

Support Vector Regression-Based Optimization for Triple Friction Pendulum Bearings: Achieving Computational Efficiency [PDF]

open access: yesJournal of Soft Computing in Civil Engineering
Triple friction pendulum bearings (TFPBs) enhance the seismic resilience of base-isolated buildings. However, optimizing TFPB designs is computationally expensive, necessitating surrogate modeling techniques.
Mahnaz Akbarzaghi   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Multi-objective opimization of MIMO control system using surrogate modeling [PDF]

open access: yes, 2012
A multi-objective optimization approach using surrogate modeling is applied to a nonlinear Multi Input Multi Outputs (MIMO) control system model to predict Pareto-front of objective functions which is defined using Integral Square Error (ISE). Typically,
Nor Shah, Mohd. Fauzi
core  

Efficient Surrogate Modeling for Sustainable Management of Complex Seawater Intrusion-Impacted Aquifers: Progress Report

open access: yes, 2022
Summary of 2021 Project Progress Report submitted to NSFProject Title: CBET-EPSRC Efficient Surrogate Modeling for Sustainable Management of Complex Seawater Intrusion-Impacted Aquifers.
Alex S. Mayer (12244638)   +1 more
core   +1 more source

A Surrogate Modeling Approach for the Development of Biorefineries

open access: yesFrontiers in Chemical Engineering, 2020
Biorefinery processes are challenged to make effective use of commercial flowsheeting software. Challenges include the lack of property data, complexity of raw materials, and emerging non-conventional processes and technologies.
Aikaterini D. Mountraki   +4 more
doaj   +1 more source

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