Results 71 to 80 of about 2,763,762 (257)

Grid Enabled Surrogate Modeling

, 2009
The simulation and optimization of complex systems is a very time consuming and computationally intensive task. Therefore, global surrogate modeling methods are often used for the efficient exploration of the design space, as they reduce the number of ...
Tom Dhaene, Dirk Gorissen, Piet Demeester, Jan Broeckhove   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Surfaces of coastal biogenic structures: exploiting advanced digital design and fabrication strategies for the manufacturing of oyster reef and mussel bed surrogates

Frontiers in Marine Science
Coastal biogenic structures, formed by ecosystem engineering species, often feature rough surfaces characterized by intricate topographies and highly three-dimensional reliefs.
Jan Hitzegrad, Leon Brohmann, Friedrich Herding, Kai Pfennings, Sven Jonischkies, Elisa Scharnbeck, Jeldrik Mainka, Inka Mai, Inka Mai, Christian Windt, Harald Kloft, Achim Wehrmann, Dirk Lowke, Dirk Lowke, Nils Goseberg, Nils Goseberg   +15 more
doaj   +1 more source

From seasonal field study to surrogate modeling: Investigating the biomechanical dynamics of Elymus sp. in salt marshes

This dataset details the data addressed and analyzed in Keimer et al., titled "From seasonal field study to surrogate modeling: Investigating the biomechanical dynamics of Elymus sp. in salt marshes". This study conducted monthly field campaigns focusing
Kind, Felix, Niewerth, Stephan, Aberle, Jochen, Schürenkamp, David, Prinz, Markus, Goseberg, Nils, Keimer, Kara, Kosmalla, Viktoria, Lojek, Oliver, Prüter, Inga   +9 more
core   +1 more source

Surrogate-Aloud: A Human Surrogate Method for Remote Usability Evaluation and Ideation in Virtual Reality

, 2021
Virtual and augmented reality offer comparative performance in terms of remote usability testing to lab-based co-located settings. However, direct contact with a researcher is still required to provide setup, troubleshoot, and training. In this paper, we
Andrew Irlitti (15472100), Thuong Hoang (13097670), Frank Vetere (13456686)   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Prediction of surface settlement caused by synchronous grouting during shield tunneling in coarse-grained soils: A combined FEM and machine learning approach

Underground Space
This paper presents a surrogate modeling approach for predicting ground surface settlement caused by synchronous grouting during shield tunneling process.
Chao Liu, Zepan Wang, Hai Liu, Jie Cui, Xiangyun Huang, Lixing Ma, Shuang Zheng   +6 more
doaj   +1 more source

Selecting the Best Quantity and Variety of Surrogates for an Ensemble Model

Mathematics, 2020
Surrogate modeling techniques are widely used to replace the computationally expensive black-box functions in engineering. As a combination of individual surrogate models, an ensemble of surrogates is preferred due to its strong robustness.
Pengcheng Ye, Guang Pan
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source