Results 81 to 90 of about 59,334 (307)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Comparing Random forest and Kriging Methods for Surrogate Modeling

, 2020
The issue with conducting real experiments in design engineering is the cost factor to find an optimal design that fulfills all design requirements and constraints. An alternate method of a real experiment that is performed by engineers is computer-aided
Asritha, Kotha Sri Lakshmi Kamakshi
core  

Dynamic Surrogate Modeling for Continuous Processes Control Applications

, 2022
International audienceWith the increasing amount of data to quickly process, surrogate modeling has become a topic of major interest in process engineering during the last decades.
Montastruc, Ludovic, Flavio Manenti, Ludovic Montastruc, Di Pretoro, Alessandro, Manenti, Flavio, Tomaselli, Andrea, Alessandro Di Pretoro, Andrea Tomaselli   +7 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Rapid Design and Fabrication of Body Conformable Surfaces with Kirigami Cutting and Machine Learning

Advanced Science
By integrating the principles of kirigami cutting and data‐driven modeling, this study aims to develop a personalized, rapid, and low‐cost design and fabrication pipeline for creating body‐conformable surfaces around the knee joint.
Jyotshna Bali, Jinyang Li, Jie chen, Suyi Li   +3 more
doaj   +1 more source

A Hybrid-Surrogate-Calibration-Assisted Multi-Fidelity Modeling Approach and Its Application in Strength Prediction for Underwater Gliders

Journal of Marine Science and Engineering
Multi-fidelity surrogate-based methods play an important role in modern engineering design applications, aiming to improve model accuracy while reducing computational cost.
Chengshan Li, Yufan Cao, Xiaoyi An, Da Lyu, Junxiao Liu   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Double surrogate modeling usage in PSO

, 2017
Purpose The purpose of this paper is to improve the efficiency of particle optimization method by using direct and indirect surrogate modeling in inverse design problems. Design/methodology/approach The new algorithm emphasizes the use of a direct and
Volkan Yasin Pehlivanoglu
core   +1 more source

Selecting the Best Quantity and Variety of Surrogates for an Ensemble Model

Mathematics, 2020
Surrogate modeling techniques are widely used to replace the computationally expensive black-box functions in engineering. As a combination of individual surrogate models, an ensemble of surrogates is preferred due to its strong robustness.
Pengcheng Ye, Guang Pan
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source