Results 101 to 110 of about 2,763,762 (257)

On using surrogates with genetic programming [PDF]

open access: yes, 2014
One way to accelerate evolutionary algorithms with expensive fitness evaluations is to combine them with surrogate models. Surrogate models are efficiently computable approximations of the fitness function, derived by means of statistical or machine ...
Branke, Jürgen, Hildebrandt, Torsten
core   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Comprehensive multi-objective optimization framework for sustainable urban flyover design: integrating radial basis function metamodeling and advanced optimization algorithms

open access: yesFrontiers in Built Environment
IntroductionUrban flyover infrastructure requires balancing structural efficiency, cost minimization, and environmental sustainability. Traditional deterministic methods fail to capture variability and reproducibility in large-scale civil projects ...
Jaya Rajkumar Ramchandani   +1 more
doaj   +1 more source

Cardiovascular Modeling With Adapted Parametric Inference

open access: yesESAIM: Proceedings and Surveys, 2018
Computational modeling of the cardiovascular system, promoted by the advance of fluid-structure interaction numerical methods, has made great progress towards the development of patient-specific numerical aids to diagnosis, risk prediction, intervention ...
Lucor Didier, Le Maître Olivier P.
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Machine-learning surrogate modeling approaches used in electromechanical systems and electrical components [PDF]

open access: yes
This bachelor’s thesis focuses on machine learning surrogate modeling approach used in electromechanical systems and electrical components. Modern electromechanical systems essentially include mechanical, electronic, and computational technologies which ...
Liu, Yaxuan
core   +1 more source

Symmetric Positive Definite Convolutional Network for Surrogate Modeling and Optimization of Modular Structures

open access: yes
This is the training data for the paper "Symmetric Positive Definite Convolutional Network for Surrogate Modeling and Optimization of Modular ...
Gaynutdinova, Liya   +7 more
core   +1 more source

Multi-objective opimization of MIMO control system using surrogate modeling [PDF]

open access: yes, 2012
A multi-objective optimization approach using surrogate modeling is applied to a nonlinear Multi Input Multi Outputs (MIMO) control system model to predict Pareto-front of objective functions which is defined using Integral Square Error (ISE). Typically,
Nor Shah, Mohd. Fauzi
core  

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