Results 111 to 120 of about 59,334 (307)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Hierarchical Gaussian Process Surrogate Modeling Framework for Heterogeneous Multi-Fidelity Dataset

, 2023
Multi-fidelity (MF) surrogate modeling has been used to a variety of situations in the last few decades. The MF surrogate model integrates data from different levels of fidelity to enhance the efficiency of surrogate modeling. However, the majority of MF
Lee, Min Gyu, Lee, Bong Jae, Lee, Ikjin, Lee, Juyoung   +3 more
core  

Creating a Real‐Time Capable Surrogate Model of a Wind Turbine Using Machine Learning

Wind Energy
Multibody simulation (MBS) is an established method for modeling wind turbines for purposes such as load calculation. While capable of modeling wind turbines at high levels of detail, large MBS models can be computationally expensive.
Stefan Witter, Jakob Roth, Ralf Schelenz, Georg Jacobs   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Design optimization of an automobile torque arm using global and successive surrogate modeling approaches

, 2018
The design of lightweight automotive structures has become a prevalent practice in the automotive industry. This study focuses on design optimization of an automobile torque arm subjected to cyclic loading. Starting from an available initial design, the
Mehmet Ali Güler, Nahide Tüten, Acar, Erdem, Erdem Acar, Güler, Mehmet Ali, Ten, Nahide   +5 more
core   +1 more source

Accurate and uncertainty-aware multi-task prediction of HEA properties using prior-guided deep Gaussian processes

npj Computational Materials
Surrogate modeling techniques have become indispensable in accelerating the discovery and optimization of high-entropy alloys (HEAs), especially when integrating computational predictions with sparse experimental observations.
Sk Md Ahnaf Akif Alvi, Mrinalini Mulukutla, Nicolás Flores, Danial Khatamsaz, Jan Janssen, Danny Perez, Douglas Allaire, Vahid Attari, Raymundo Arróyave   +8 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Introduction of Applied Aerodynamics Surrogate Modeling Benchmark Cases

From aircraft design to certification, a significant volume of aerodynamic data is required to ensure optimal performance, meet regulatory standards, and maintain structural integrity.
Cornelius, Jason, Bekemeyer, Philipp, Hariharan, Nathan, Wissink, Andrew   +3 more
core   +1 more source

Cardiovascular Modeling With Adapted Parametric Inference

ESAIM: Proceedings and Surveys, 2018
Computational modeling of the cardiovascular system, promoted by the advance of fluid-structure interaction numerical methods, has made great progress towards the development of patient-specific numerical aids to diagnosis, risk prediction, intervention ...
Lucor Didier, Le Maître Olivier P.
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source