Results 111 to 120 of about 24,324,331 (382)

A Hybrid-Surrogate-Calibration-Assisted Multi-Fidelity Modeling Approach and Its Application in Strength Prediction for Underwater Gliders

Journal of Marine Science and Engineering
Multi-fidelity surrogate-based methods play an important role in modern engineering design applications, aiming to improve model accuracy while reducing computational cost.
Chengshan Li, Yufan Cao, Xiaoyi An, Da Lyu, Junxiao Liu   +4 more
doaj   +1 more source

Solving the G-problems in less than 500 iterations: Improved efficient constrained optimization by surrogate modeling and adaptive parameter control [PDF]

, 2015
Constrained optimization of high-dimensional numerical problems plays an important role in many scientific and industrial applications. Function evaluations in many industrial applications are severely limited and no analytical information about ...
Bagheri, Samineh, Bäck, Thomas, Emmerich, Michael, Konen, Wolfgang   +3 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Surfaces of coastal biogenic structures: exploiting advanced digital design and fabrication strategies for the manufacturing of oyster reef and mussel bed surrogates

Frontiers in Marine Science
Coastal biogenic structures, formed by ecosystem engineering species, often feature rough surfaces characterized by intricate topographies and highly three-dimensional reliefs.
Jan Hitzegrad, Leon Brohmann, Friedrich Herding, Kai Pfennings, Sven Jonischkies, Elisa Scharnbeck, Jeldrik Mainka, Inka Mai, Inka Mai, Christian Windt, Harald Kloft, Achim Wehrmann, Dirk Lowke, Dirk Lowke, Nils Goseberg, Nils Goseberg   +15 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Prediction of surface settlement caused by synchronous grouting during shield tunneling in coarse-grained soils: A combined FEM and machine learning approach

Underground Space
This paper presents a surrogate modeling approach for predicting ground surface settlement caused by synchronous grouting during shield tunneling process.
Chao Liu, Zepan Wang, Hai Liu, Jie Cui, Xiangyun Huang, Lixing Ma, Shuang Zheng   +6 more
doaj   +1 more source

Surrogate modeling of advanced computer simulations using deep Gaussian processes

Reliability Engineering & System Safety, 2020
The continuous advancements in computer power and computational modeling through high-fidelity and multiphysics simulations add more challenges on assessing their predictive capability.
M. Radaideh, T. Kozłowski
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AI-based optimization of PEM fuel cell catalyst layers for maximum power density via data-driven surrogate modeling

, 2020
© 2020 Elsevier Ltd Catalyst layer (CL) is the core electrochemical reaction region of proton exchange membrane fuel cells (PEMFCs). Its composition directly determines PEMFC output performance.
Bowen Wang, Biao Xie, J. Xuan, K. Jiao
semanticscholar   +1 more source