Results 121 to 130 of about 59,334 (307)

Multiobjective global surrogate modeling, dealing with the 5-percent problem [PDF]

, 2010
When dealing with computationally expensive simulation codes or process measurement data, surrogate modeling methods are firmly established as facilitators for design space exploration, sensitivity analysis, visualization, prototyping and optimization ...
Laermans, Eric, Dhaene, Tom, Gorissen, Dirk, Couckuyt, Ivo   +3 more
core   +1 more source

Comprehensive multi-objective optimization framework for sustainable urban flyover design: integrating radial basis function metamodeling and advanced optimization algorithms

Frontiers in Built Environment
IntroductionUrban flyover infrastructure requires balancing structural efficiency, cost minimization, and environmental sustainability. Traditional deterministic methods fail to capture variability and reproducibility in large-scale civil projects ...
Jaya Rajkumar Ramchandani, Suddhasheel Ghosh   +1 more
doaj   +1 more source

DEVELOPMENT OF WATER QUALITY MATRIX THROUGH SURROGATE MODELING

EQA, 2018
This paper presents the outcome of a research project that was focused on the monitoring of surface water quality through the development of a correlation matrix.
Laura Kusari
doaj   +1 more source

Pca & Kriging For Surrogate Models

2nd General Meeting and 2nd Workshop on Smart Energy Carriers in Industry, 2016
Presentation at the 2nd General Meeting and 2nd Workshop on Smart Energy Carriers in ...
Aversano, Gianmarco, Gicquel, Olivier, Parente, Alessandro   +2 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Automated ICRF heating surrogate modeling via machine learning [PDF]

EPJ Web of Conferences
This work introduces automated machine learning workflows that address critical bottlenecks in surrogate model development for Ion Cyclotron Range of Frequencies (ICRF) heating applications.
Sanchez-Villar Alvaro, Bertelli Nicola, Shiraiwa Syun’ichi, Bai Zhe, Perciano Talita, Bethel E. Wes, Hillairet Julien, Miller Joseph, Wallace Gregory M., Wright John C.   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Surrogate-assisted evolutionary algorithms for expensive combinatorial optimization: a survey

Complex & Intelligent Systems
As potent approaches for addressing computationally expensive optimization problems, surrogate-assisted evolutionary algorithms (SAEAs) have garnered increasing attention.
Shulei Liu, Handing Wang, Wei Peng, Wen Yao   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source