Results 121 to 130 of about 2,763,762 (257)

Generative prediction of laser-induced rocket ignition with dynamic latent space representations

Data-Centric Engineering
Accurate and predictive scale-resolving simulations of laser-ignited rocket engines are highly time-consuming because the problem includes turbulent fuel–oxidizer mixing dynamics, laser-induced energy deposition, and high-speed flame growth.
Tony Zahtila, Ettore Saetta, Murray Cutforth, Davy Brouzet, Diego Rossinelli, Gianluca Iaccarino   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

IMPROVED PARTICLE SWARM OPTIMIZATION METHOD DIRECTED BY INDIRECT SURROGATE MODELING

Havacılık ve Uzay Teknolojileri Dergisi, 2015
An improved particle swarm optimization algorithm is proposed and tested for two different test cases: surface fitting of a wing shape and an inverse design of an airfoil in subsonic flow.
Yasin Volkan Pehlivanoğlu, Serdar Ay, Faruk Gül   +2 more
doaj  

Robust optimization of fully coupled geothermal reservoir and power plant system based on deep learning

Energy Conversion and Management: X
In geothermal recovery, the reservoir production temperature decline can affect the power plant’s efficiency and electricity output. Therefore, the coupling between the reservoir and the power plant is crucial for accurate estimation of the power plant’s
Ziyou Liu, Manojkumar Gudala, Klemens Katterbauer, Bicheng Yan   +3 more
doaj   +1 more source

Multifidelity surrogate modeling of experimental and computational aerodynamic data sets

, 2011
This study presents a multifidelity surrogate modeling approach, combining experimental and computational aerodynamic data sets. A multifidelity cokriging regression surrogate model is used.
Zhang, Xin, Takeda, Kenji, Xin Zhang, Kenji Takeda, Forrester, Alexander I.J., Alexander I. J. Forrester, Kuya, Yuichi, Forrester, Alexander, Yuichi Kuya   +8 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

An efficient surrogate-assisted hybrid optimization framework for polymer flooding management

Journal of Petroleum Exploration and Production Technology
Reservoir injection-production optimization is critical for enhancing oil recovery in high-water-cut mature fields. Polymer flooding improves development efficiency by increasing fluid viscosity and controlling mobility, yet its optimization faces ...
Gaocheng Feng, Kai Zhang, Huan Wan, Weiying Yao, Zhiyong Wei, Qiuyue Chen, Ang Li   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source