Results 141 to 150 of about 24,324,331 (382)
Recurrent convolutional neural network for the surrogate modeling of subsurface flow simulation [PDF]
, 2020 Hyung Jun Yang, Timothy Yeo, Jaewoo An
openalex +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Surrogate-based aerodynamic optimization of proprotor blades for a parcel delivery UAV [PDF]
INCAS BulletinThis study presents a surrogate-based aerodynamic optimization framework for a quad-tiltrotor platform designed for both hover and forward flight. To obtain an optimized blade design in both hover and forward flight conditions, a free wake model is ...
Sooin PARK, Usama YOUNUS
doaj +1 more source
Towards Neural Speaker Modeling in Multi-Party Conversation: The Task, Dataset, and Models
, 2018 Neural network-based dialog systems are attracting increasing attention in both academia and industry. Recently, researchers have begun to realize the importance of speaker modeling in neural dialog systems, but there lacks established tasks and datasets.
Jin, Zhi, Meng, Zhao, Mou, Lili
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Surrogate-assisted evolutionary algorithms for expensive combinatorial optimization: a survey
Complex & Intelligent SystemsAs potent approaches for addressing computationally expensive optimization problems, surrogate-assisted evolutionary algorithms (SAEAs) have garnered increasing attention.
Shulei Liu +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source