Results 161 to 170 of about 2,763,762 (257)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Data-based surrogate modeling and performance prediction of MEMS touch mode capacitive sensing using deep multilayer perceptron networks. [PDF]

Front Artif Intell
E P, Jindal SK.
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Fractional Physics Informed Neural Networks for Surrogate Modeling of Non-Markovian Discrete-Time Quantum Walks. [PDF]

Entropy (Basel)
Zhu Z, Liu M, Liang C, Yang F, Shen J, Wen X, Shen L, Wang Y.   +7 more
europepmc   +1 more source

Connecting Agent-Based Models with High-Dimensional Parameter Spaces to Multidimensional Data Using SMoRe ParS: A Surrogate Modeling Approach. [PDF]

Bull Math Biol, 2023
Bergman DR, Norton KA, Jain HV, Jackson T.   +3 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Machine Learning-Driven Surrogate Modeling and Operating-Point Selection for a Microfluidic Diffusion-Membrane Platform for Transdermal Drug Delivery. [PDF]

Membranes (Basel)
Torabi T, Harasy MJ, Tahmoresnezhad J, Malekmohammadi S, Iulianelli A, Ghasemzadeh K.   +5 more
europepmc   +1 more source

Multi-Fidelity Gaussian Process Surrogate Modeling of Pediatric Tissue Expansion. [PDF]

J Biomech Eng, 2022
Han T, Ahmed KS, Gosain AK, Tepole AB, Lee T.   +4 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Physics informed neural network surrogate modeling and global sensitivity analysis of magnetized nanofluid flow over a porous cylinder for solar thermal energy applications. [PDF]

Discov Nano
Hussain M, Alhushaybari A.
europepmc   +1 more source