Results 151 to 160 of about 24,324,331 (382)

Channel Effects on Surrogate Models of Adversarial Attacks against Wireless Signal Classifiers [PDF]

, 2020
Brian Kim, Yalin E. Sagduyu, Tugba Erpek, Kemal Davaslıoğlu, Şennur Ulukuş   +4 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Numerical Investigation and Optimization of a Flushwall Injector for Scramjet Applications at Hypervelocity Flow Conditions [PDF]

An investigation utilizing Reynolds-averaged simulations (RAS) was performed in order to demonstrate the use of design and analysis of computer experiments (DACE) methods in Sandias DAKOTA software package for surrogate modeling and optimization.
Axdahl, Erik L., Baurle, Robert A., Drozda, Tomasz G., Shenoy, Rajiv R.   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A cGAN Ensemble-based Uncertainty-aware Surrogate Model for Offline Model-based Optimization in Industrial Control Problems [PDF]

, 2022
Feng, Cheng
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Robust optimization of fully coupled geothermal reservoir and power plant system based on deep learning

Energy Conversion and Management: X
In geothermal recovery, the reservoir production temperature decline can affect the power plant’s efficiency and electricity output. Therefore, the coupling between the reservoir and the power plant is crucial for accurate estimation of the power plant’s
Ziyou Liu, Manojkumar Gudala, Klemens Katterbauer, Bicheng Yan   +3 more
doaj   +1 more source

Optimising of vacuum distillation units using surrogate models

, 2021
Shi Xie H’ng, Lucas Ng, Denny K. S. Ng, Viknesh Andiappan   +3 more
openalex   +1 more source

Surrogate Modeling: Review and Opportunities for Expert Knowledge Integration

Procedia Computer Science
Digital Twins (DTs), essential for digitalization and Industry 4.0, demand high-fidelity yet computationally efficient models for real-time replication of physical systems. However, simulating continuous dynamical systems, often stiff and highly granular, poses significant computational challenges.
Šturek, Dušan, Lazarova-Molnar, Sanja
openaire   +3 more sources