Results 41 to 50 of about 456,731 (293)

Making global sensitivity analysis feasible using neural network surrogates

Data-Centric Engineering
How can we make global sensitivity analysis accessible and viable for engineering practice? In this translation article, we present a methodology to enable sensitivity analysis for structural and geotechnical engineering for built environment design and ...
Gihan Weerasinghe, Ramaseshan Kannan, Samila Bandara   +2 more
doaj   +1 more source

MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou, Regina Kubica, Karen Fischhuber, Jasmin Beygo, Madlen Reschke, Petra Ritter‐Sovinz, Eva Biewald, Petra Ketteler, Dietmar Lohmann, Deniz Kanber   +9 more
wiley   +1 more source

Model-Based Sequential Design of Experiments with Machine Learning for Aerospace Systems

Aerospace
Traditional experimental design methods often face challenges in handling complex aerospace systems due to the high dimensionality and nonlinear behavior of such systems, resulting in nonoptimal experimental designs.
Tim Gerling, Kai Dresia, Jan Deeken, Günther Waxenegger-Wilfing   +3 more
doaj   +1 more source

Kernel Methods for Surrogate Modeling

, 2019
This chapter deals with kernel methods as a special class of techniques for surrogate modeling. Kernel methods have proven to be efficient in machine learning, pattern recognition and signal analysis due to their flexibility, excellent experimental performance and elegant functional analytic background.
Santin G., Haasdonk B.
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Integration of value and sustainability assessment in design space exploration by machine learning: an aerospace application

Design Science, 2020
The use of decision-making models in the early stages of the development of complex products and technologies is a well-established practice in industry.
Alessandro Bertoni, Sophie I. Hallstedt, Siva Krishna Dasari, Petter Andersson   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

MATSuMoTo: The MATLAB Surrogate Model Toolbox For Computationally Expensive Black-Box Global Optimization Problems [PDF]

, 2014
MATSuMoTo is the MATLAB Surrogate Model Toolbox for computationally expensive, black-box, global optimization problems that may have continuous, mixed-integer, or pure integer variables.
Mueller, Juliane
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Increasing Superstructure Optimization Capacity Through Self-Learning Surrogate Models

Frontiers in Chemical Engineering, 2021
Simulation-based optimization models are widely applied to find optimal operating conditions of processes. Often, computational challenges arise from model complexity, making the generation of reliable design solutions difficult.
Julia Granacher, Ivan Daniel Kantor, Ivan Daniel Kantor, François Maréchal   +3 more
doaj   +1 more source