Results 71 to 80 of about 17,596 (295)
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Insight into different aspects of surrogacy practices
Journal of Human Reproductive Sciences, 2018 Surrogacy is an important method of assisted reproductive technology wherein a woman carries pregnancy for another couple. Number of couples around the world require surrogacy services for various reasons. Although this arrangement seems to be beneficial
Nayana Hitesh Patel +5 more
doaj +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
, 2010 This thesis deals with the current issue of the Institute of the ``Surrogate Mother{\crqq} with attention to the ethical and the juridical field. The theoretical part characterises the idea of the Surrogate Motherhood, handles the juridical relations ...
DULAWOVÁ, Ingrid
core
Ultrasound‐Actuated Gene Editing in Human Kidney Organoids
Advanced Science, EarlyView.Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller +6 more
wiley +1 more source
The Effects of Sperm and Seminal Fluid of Immunized Male Mice on In Vitro Fertilization and Surrogate Mother-Embryo Interaction. [PDF]
Int J Mol Sci, 2021 Kontsevaya GV +6 more
europepmc +1 more source
ANALISA YURIDIS SURROGATE MOTHER DARI ASPEK SAHNYA PERJANJIAN
, 2017 Humans are created in pairs for future descendants (grandchildren), but not all pairs of humans can have children/ offspring with various causes. It turns out to be overcome by In Vitro Fertilization, one of which is Surrogate Mother, which is a woman ...
Situmeang, Tomson
core +1 more source
Advanced Science, EarlyView.High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott +5 more
wiley +1 more source
Advanced Science, EarlyView.Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia +4 more
wiley +1 more source