Results 101 to 110 of about 17,967 (297)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

open access: yesAdvanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li   +15 more
wiley   +1 more source

Surrogate (Replacement) Motherhood or Should the Uterus be Rented?

open access: yesPannoniana, 2019
After the birth of the “test-tube baby,” the triumphant success of reproductive technologies has dramatically accelerated scientific research in many fields and given hope to couples struggling with the problem of infertility.
Dejan Donev
doaj  

Human Rights Questions: From Bioethics to Biolaw [PDF]

open access: yes
Bioethics as a pluridisciplinary activity aims to clarify and solve actual ethical problems generated by science and bio-medical technologies. The gap between the scientific and medical progress and the law generally and Human Rights especially does not ...
Aurora CIUCA
core   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li   +10 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

open access: yesAdvanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia   +4 more
wiley   +1 more source

A View of Civil Law and Islamic Law on the Practice of Surrogate Mother

open access: yesYurisdiksi: Jurnal Wacana Hukum dan Sains
IVF is one of the modern methods that can help legal couples obtain children. Both Indonesian Civil Law and Islamic Law allow this practice. Still, it must be carried out based on the provisions, namely by involving couples who are legal in the eyes of ...
Muhammad Ridwan, M. Junaidi
doaj   +1 more source

Review of Islam and New Kinship: Reproductive Technology and the Shariah in Lebanon, Fertility, Reproduction and Sexuality. (Book Review) Review of When God Comes to Town: Religious Traditions in Urban Contexts Editors: Rik Pinxten and Lisa Dikomitis (Book Review) [PDF]

open access: yes, 2010
Reviews of: Islam and New Kinship: Reproductive Technology and the Shariah in Lebanon, Fertility, Reproduction and Sexuality series vol. 16, New York & Oxford: Berghahn Books.
Bigger, Stephen
core   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

open access: yesAdvanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan   +13 more
wiley   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

open access: yesAdvanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang   +8 more
wiley   +1 more source

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