Results 91 to 100 of about 2,534 (257)

PROTECTION OF HUMAN RIGHTS IN THE CONTEXT OF THE DEVELOPMENT OF BIOETHICS AND GENOMICS (THEMATIC REVIEW OF THE INTERNATIONAL ROUND TABLE)

RUDN Journal of Law, 2019
The article presents a description of the main theses of reports and presentations during the thematic meeting in the framework of an interdisciplinary group of scientific experts and students of law schools from Russia and Italy.
Elena N Trikoz
doaj   +1 more source

A Relational Defence of Surrogate Motherhood [PDF]

, 2011
A Relational Defence of Surrogate Motherhood Pauline Everett This thesis explores surrogate motherhood using Christian ethics within a relational framework.
EVERETT, PAULINE
core  

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

The legal issues of a surrogate motherhood

, 2013
Die vorliegende Arbeit setzt sich mit den rechtlichen Problemen einer Leihmutterschaft auseinander. Bei der Leihmutterschaft erklärt sich eine Frau vertraglich dazu bereit, für eine andere Frau ein Kind auszutragen und dieses sodann nach der Geburt an ...
Morak, Tanja
core   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Surrogate motherhood conception in the heart

, 1994
"Ever since the Baby M case, the public has been fascinated with the continuing phenomenon of surrogate motherhood. The Baby M case raised, and left unanswered, many questions about what constitutes motherhood, fatherhood, family, reproduction, and ...
Ragoné, Helena
core  

Surrogate motherhood and rights

, 2020
This doctoral thesis discusses the notion of surrogacy as a method of childbearing by childless couples. The aim of this research is to analyze the rights of social parents and surrogate mother, to clarify the aspects and problems that surrogacy arises ...
Σακελλαράκη, Καλομοίρα, Sakellaraki, Kalomoira   +1 more
core   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source