Results 31 to 40 of about 52,338 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanical mechanism and morphological characteristics of fracture range formation in surrounding rock of soft rock roadway

Meitan xuebao
After the excavation of the roadway, the broken expansion and shear expansion of the surrounding rock along the crack surface are the important reasons for the large deformation of the surrounding rock, and the broken expansion and shear expansion of the
Yujie MA, Weijun WANG, Chao YUAN, Hai WU, Xinyu TIAN, Shihai SHU, Sha GE   +6 more
doaj   +1 more source

Research on the “three shells” cooperative support technology of large-section chambers in deep mines

International Journal of Mining Science and Technology, 2021
The “three shells” cooperative support technology was proposed herein according to both the large deformation of the rock surrounding large-section chambers in deep mines and the precarious stability of the support structures therein.
Cheng Zhu, Yong Yuan, Wenmiao Wang, Zhongshun Chen, Shengzhi Wang, Huiwei Zhong   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Numerical Simulation Analysis Method of the Surrounding Rock and Support Bearing Capacity in Underground Cavern

Energies, 2022
After the excavation of an underground cavern, how the surrounding rock and the support work together to bear the excavation load is an important prerequisite to correctly analyze the joint force characteristics; effectively play the role of support; and
Ming Xiao, Junqing Ren, Binxin Zhao, Chen Chen, Shijie Chen   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

A Real-Time Inverted Velocity Model for Fault Detection in Deep-Buried Hard Rock Tunnels Based on a Microseismic Monitoring System

Buildings
Microseismic monitoring is an effective and widely used technology for dynamic fault disaster early warning and prevention in deep-buried hard rock tunnels.
Houlin Xie, Bingrui Chen, Qian Liu, Yaxun Xiao, Liu Liu, Xinhao Zhu, Pengxiang Li   +6 more
doaj   +1 more source

Leveraging Symbolic Artificial Intelligence and Fuzzy Logic for Materials Science: A Review of Methods, Challenges, and Applications to Scarce and Imperfect Experimental Data

Advanced Engineering Materials, EarlyView.
This article explores the transformative potential of symbolic artificial intelligence (AI) in the field of materials science, particularly in leveraging experimental data. The article presents several symbolic AI models and discusses their applications in materials science.
Ahmed Amrani, Mohamed‐Ali Belloum, Laurence Boudet, Valentin Fouillard, Edwin Friedmann, Guillaume Lacharme, Ali Mahmoud, Jean‐Philippe Poli   +7 more
wiley   +1 more source