Results 41 to 50 of about 64,455 (258)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multi-echelon support of surrounding rock.

, 2018
Multi-echelon support of surrounding rock.
Guangming Zhao (2921958), Rui Peng (472678), Yingming Li (2208538), Jianming Zhu (1393405), Xiangrui Meng (3566795)   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Research progress of support theory and technology of the roadway surrounding rock based on the plastic zone control

Meitan xuebao
With the increasing depth of coal mining, the stability control of surrounding rock in deep roadway has become one of major problems in the mining field, and the effect of surrounding rock control in deep roadway is directly related to the safe ...
Weijun WANG, Lei FAN, Zhiqiang ZHAO, Sen HAN   +3 more
doaj   +1 more source

Factors influencing the anti-impact performance of a “roadway rock support” system

Frontiers in Earth Science, 2023
A mechanical model of a circular section of a tunnel roadway considering damage is established to improve the impact protection performance of the “roadway rock-support” system and provide a theoretical basis for designing coal mine impact ground ...
Zhi Tang, Wenbo Zuo, Ke Gao, Xiaoqiao Cai   +3 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

A Real-Time Inverted Velocity Model for Fault Detection in Deep-Buried Hard Rock Tunnels Based on a Microseismic Monitoring System

Buildings
Microseismic monitoring is an effective and widely used technology for dynamic fault disaster early warning and prevention in deep-buried hard rock tunnels.
Houlin Xie, Bingrui Chen, Qian Liu, Yaxun Xiao, Liu Liu, Xinhao Zhu, Pengxiang Li   +6 more
doaj   +1 more source

Rock Hill Viewbook Rock Hill is a Good Town - Accession 1091 - M501 (551) [PDF]

, 2016
This collection consists of Rock Hill Is a Good Town: Rock Hill South Carolina 1912 which was a viewbook produced by the town of Rock Hill, SC as a pictorial guide and as an invitation to potential newcomers.
Rock Hill, SC
core  

Stress and Deformation Characteristics of Tunnel Surrounding Rock under Alteration

, 2023
Based on a typical project in an altered rock area, this study carried out numerical simulations using the FLAC3D software to calculate the changes in the stress field, deformation field, and plastic zone of the surrounding rock during the unsupported ...
Jianyong Li, Xiaoshi Yan, Jinyu Dong, Yapeng Chen, Tong Wu, Shang Shi   +5 more
core   +1 more source