Results 111 to 120 of about 167,709 (298)
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
, 2014 A computational method of rock pressure applied to an ultra-shallow tunnel is presented by key block theory, and its mathematical formula is proposed according to a mechanical tunnel model with super-shallow depth.
X. Zhou, Jinghe Wang, Ben-Da Lin
semanticscholar +1 more source
Advanced Science, EarlyView.Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy +4 more
wiley +1 more source
Pressure-relief joint sample map.
To address the problem of large deformations in weak surrounding rock tunnels under high ground stress, which cause damage to initial support structures, this study proposes a novel type of circumferential pressure-relief joint based on the concept of ...
Zhiming Xu (1271712) +1 more
core +1 more source
, 2015 For problems of difficult realization of effective monitoring and poor pre-alarming ability of existing surrounding rock pressure monitoring technologies for coal mine tunneling roadway, a kind of online monitoring and pre-alarming system for surrounding
MENG Qingyong
core +1 more source
Advanced Science, EarlyView.ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
Meikuang AnquanIn order to solve the control problems of deformation and failure in soft and thick coal seam in kilometer-deep coal mine, the gob-side roadway in deep loose and weak thick coal seam is taken as the object. Based on on-site investigation and measurement,
Wenwei MA, Wenxu LIANG
doaj +1 more source
Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems
Advanced Science, EarlyView.Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen +8 more
wiley +1 more source
Scientific ReportsAddressing the insufficient pressure relief in the deep coal mass and the deterioration of the surrounding rock bearing structure due to increased borehole diameter in conventional borehole pressure relief techniques, a static expansive fracturing method
Wenyu Lyu +8 more
doaj +1 more source
Nonlinear Stability Analysis of Shallow-Buried Bias Tunnel Based on Failure Mode Improvement
Applied SciencesBased on the improvement of the Karl Terzaghi failure mode for calculating the surrounding rock pressure of loose rock mass, combined with the upper bound theorem of limit analysis, the formula for calculating the surrounding rock pressure of shallow ...
Wei Luo +5 more
doaj +1 more source