Results 221 to 230 of about 1,413,891 (297)

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

open access: yesInterdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li   +7 more
wiley   +1 more source

Bacterial Meningitis Epidemiology in Burkina Faso and Niger-High-Risk Countries in the Meningitis Belt of Sub-Saharan Africa, 2015-2023. [PDF]

open access: yesJ Infect Dis
Pinell-McNamara VA   +34 more
europepmc   +1 more source

Clinical progress note: Rotavirus

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Rotavirus is a vaccine‐preventable cause of acute, viral gastroenteritis typically characterized by diarrhea, vomiting, and fever. Prior to rotavirus vaccine introduction, nearly all children worldwide had been infected by 5 years of age. Severe rotavirus gastroenteritis causes dehydration and electrolyte derangements, and infants and young ...
Kelsey Thetford, Meghan Hofto
wiley   +1 more source

A two‐stage model for precise identification and Gleason grading of clinically significant prostate cancer: a hybrid approach

open access: yesJournal of Medical Radiation Sciences, Volume 72, Issue 1, Page 93-105, March 2025.
This study developed a two‐stage model using radiomics‐based multiparametric MRI and clinical indicators to help identify and grade clinically significant prostate cancer. The model showed promising levels of diagnostic accuracy and predictive performance.
Yuyan Zou   +10 more
wiley   +1 more source

Use of ultrasonography in assessing peri‐implant osseous defects: An in vitro study

open access: yesJournal of Periodontology, EarlyView.
Abstract Background The purpose of this study is to investigate the feasibility and diagnostic accuracy of ultrasonography in peri‐implant defect identification and evaluation, and to compare ultrasonography (USG) with cone‐beam computed tomography (CBCT) in defect identification and evaluation in an in vitro model.
Melissa Rachel Fok   +4 more
wiley   +1 more source

Predictors of early cancer burden in <i>CDH1</i> pathogenic variant carriers: a UK single-centre cohort study. [PDF]

open access: yesEClinicalMedicine
Wu L   +8 more
europepmc   +1 more source

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