Results 41 to 50 of about 121,947 (258)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of Concern

Microbiology Spectrum, 2022
The N501Y amino acid mutation caused by a single point substitution A23063T in the spike gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possessed by three variants of concern (VOCs), B.1.1.7, B.1.351, and P.1.
Mariana Abdulnoor, AliReza Eshaghi, Stephen J. Perusini, George Broukhanski, Antoine Corbeil, Kirby Cronin, Nahuel Fittipaldi, Jessica D. Forbes, Jennifer L. Guthrie, Julianne V. Kus, Ye Li, Anna Majury, Gustavo V. Mallo, Tony Mazzulli, Roberto G. Melano, Romy Olsha, Ashleigh Sullivan, Vanessa Tran, Samir N. Patel, Vanessa G. Allen, Jonathan B. Gubbay   +20 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Surveillance for Soil-Transmitted Helminths in High-Risk County, Mississippi, USA

Emerging Infectious Diseases, 2023
Recent reports of hookworm infection in Alabama, USA, has prompted surveillance in Mississippi, given the states’ similar environmental conditions. We collected stool specimens from 277 children in Rankin County, Mississippi. Kato–Katz microscopic smear,
Richard S. Bradbury, Lora Martin, Lacy Malloch, Maygan Martin, John M. Williams, Kayla Patterson, Cameron Sanders, Gurbaksh Singh, Irene Arguello, Eduardo Rodriguez, Paul Byers, Lisa Haynie, Yvonne Qvarnstrom, Charlotte V. Hobbs   +13 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Environmental Surveillance of Polio and Non-Polio Enterovi¬ruses in Sistan and Balouchestan Province [PDF]

Iranian Journal of Public Health, 2008
Background: Enteroviruses can easily circulate in the population through sewage and they are suitable indicators for environ­mental surveillance. On the other hand, in some countries there are evidences of silent circulation of viruses in sew­age ...
S Hamed Khodaei, M Kargar , H Tabatabaei , M Sarijlou , R Nategh   +4 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

HIV drug resistance surveillance using pooled pyrosequencing. [PDF]

PLoS ONE, 2010
BACKGROUND: Surveillance for HIV transmitted drug resistance (TDR) is performed using HIV genotype results from individual specimens. Pyrosequencing, through its massive parallel sequencing ability, can analyze large numbers of specimens simultaneously ...
Hezhao Ji, Nathalie Massé, Shaun Tyler, Ben Liang, Yang Li, Harriet Merks, Morag Graham, Paul Sandstrom, James Brooks   +8 more
doaj   +1 more source

Detection of Clinically Relevant Genotypes of Vancomycin-Resistant Enterococci in Nosocomial Surveillance Specimens by PCR [PDF]

Journal of Clinical Microbiology, 1999
ABSTRACT This study evaluated a PCR method for the rapid detection of clinically significant genotypes of vancomycin-resistant enterococci (VRE) in nosocomial surveillance specimens. Detection of the vanA and vanB genes by multiplex PCR using 657 specimens that showed presumptive ...
P, Jayaratne, C, Rutherford
openaire   +2 more sources

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source