Results 51 to 60 of about 121,947 (258)

Improving the specimen referral system in Ghana: findings from a landscape assessment

Frontiers in Public Health
IntroductionGhana's specimen referral system (SRS) is driven by vertical surveillance programs and outbreak response events; the lack of integration limits public health disease surveillance capacity.
Christopher Nkrumah, Paa Kobina Forson, Bernard Nkrumah, Richard Owusu, Mohammed Aminu Andrew Musah, Doreenda Enyonam Ahiataku, Gifty Boateng, Pearl Nanka-Bruce, Franklin Asiedu-Bekoe, Horlali Yao Gudjinu, William Addo Mills-Pappoe, John T. Ayivase, Ignatius Nchor Awinibuno, Danielle T. Barradas   +13 more
doaj   +1 more source

Incidence and etiology of infectious diarrhea from a facility-based surveillance system in Guatemala, 2008–2012

BMC Public Health, 2019
Background Diarrhea is a major cause of morbidity and mortality, yet incidence and etiology data are limited. We conducted laboratory-based diarrhea surveillance in Guatemala.
Wences Arvelo, Aron J. Hall, Olga Henao, Beatriz Lopez, Chris Bernart, Juan C. Moir, Lissette Reyes, Susan P. Montgomery, Oliver Morgan, Alejandra Estevez, Michele B. Parsons, Maria R. Lopez, Gerry Gomez, Jan Vinje, Nicole Gregoricus, Umesh Parashar, Eric D. Mintz, John McCracken, Joe P. Bryan, Kim A. Lindblade   +19 more
doaj   +1 more source

Intelligent Sky Guardians (InSkyGuard): An Aerial Robotic Swarm for Autonomous Detection and Entrapment of Rogue Multirotors

Advanced Robotics Research, EarlyView.
Intelligent Sky Guardians (InSkyGuard) is introduced as a four‐drone swarm that autonomously detects, tracks, and safely captures rogue drones using a coordinated net system. Computer vision and leader–follower control architecture enable synchronized enclosure, while integrated failsafes enhance system reliability. Validated through closed‐environment
Joshua Hastings, Levanya Dewanarayana, Iline Shaju, Haider Al‐Wizni, Sampson Marquis, Weicheng Huang, Pooya Sareh   +6 more
wiley   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Excluding polio in areas of inadequate surveillance in the final stages of eradication in China

Bulletin of the World Health Organization
In 1996, China adopted a virological classification of acute flaccid paralysis (AFP) cases for its surveillance system. Only AFP cases with wild poliovirus in stool specimens are confirmed as polio.
E.J. Hoekstra, Chai Feng, Wang Xiao-jun, Zhang Xing-lu, Yu Jing-jin, J. Bilous   +5 more
doaj   +1 more source

Pathological issues in biopsy specimens of men with prostate cancer eligible for active surveillance

Archivio Italiano di Urologia e Andrologia, 2014
Active surveillance (AS) is an important management option for men with lowrisk, clinically localized prostate cancer. The clinical parameters for patient selection and definition of progression for AS protocols are evolving as data from several large cohorts become mature.
Roberta, Mazzucchelli, Andrea Benedetto, Galosi, Antonio, Lopez-Beltran, Marina, Scarpelli, Liang, Cheng, Rodolfo, Montironi   +5 more
openaire   +3 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Audit of endoscopic surveillance biopsy specimens in HIV positive patients with gastrointestinal symptoms. [PDF]

Gut, 1993
An audit of upper gastrointestinal endoscopy in HIV infected patients with gastrointestinal symptoms assessed the frequency of disease detected by endoscopy and routine laboratory analysis of surveillance biopsy specimens. Sixty nine consecutive endoscopies were performed in 59 HIV infected patients.
S G, Lim, M C, Lipman, S, Squire, D, Pillay, S, Gillespie, E A, Sankey, A P, Dhillon, M A, Johnson, C A, Lee, R E, Pounder   +9 more
openaire   +2 more sources

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source