Results 41 to 50 of about 13,591,349 (287)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dis-ease Surveillance: How Might Surveillance Studies Address COVID-19?

, 2020
We are currently in the midst of a global pandemic with the spread of Coronavirus Disease 2019 (COVID-19). While we do not know how this situation will unfold or resolve, we do have insight into how it fits within existing patterns and relations ...
French, Martin, Monahan, Torin
core   +1 more source

Health risk communication and infodemic management in Iran: development and validation of a conceptual framework

BMJ Open, 2023
Objective The COVID-19 pandemic exposed significant gaps in Iran’s and other health systems’ risk communication. The accompanying infodemic undermined policy responses, amplified distrust in government and reduced adherence to public health ...
Hamid Sharifi, Jaason Geerts, Azam Bazrafshan, Azadeh Sadeghi, Maliheh Sadat Bazrafshan, Hossein Mirzaie, Mehdi Shafiee   +6 more
doaj   +1 more source

Exploring Terra Incognita : Mapping Surveillance Studies from the Perspective of Media and Communication Research

, 2015
This article attempts to map Surveillance Studies from the perspective of the academic field of media and communication studies,and to seek out boundaries, limitations, strengths and weaknesses of current research.
Mehrabov, Ilkin, Mehrabov, Ilkin,
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mainstreaming Colonial Experiences in Surveillance Studies

, 2019
Decolonizing surveillance studies is an urgent task, needed to comprehend the unequal impacts of surveillance technologies in the past, present, and future.
Ogasawara, Midori
core   +1 more source

HIV testing trend and associated factors among people who inject drugs in Iran (2010–2020)

Harm Reduction Journal
Background HIV testing is critical for HIV prevention and treatment among PWID and their social networks. This study aimed to examine the trend of HIV testing among PWID in Iran. We also assessed the factors associated with HIV testing in 2020.
Parya Jangipour Afshar, Mohammad Karamouzian, Ali Akbar Haghdoost, Mehrdad Khezri, Ali Mirzazadeh, Fatemeh Tavakoli, Mostafa Shokoohi, Soheil Mehmandoost, Nima Ghalekhani, Hossein Mirzaei, Hamid Sharifi   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source