Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Avon Downs, Northern Territory [cartographic material].
, 1942 1st ed. "Drawn and Reproduced by L.H.Q. (Aust.) Cartographic Company. 1942."; Catalogue record generated as part of a batch load.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Australia. Army. Survey Corps.
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
La Grange, Western Australia [cartographic material].
, 1942 1st ed. "Printed by A.H.Q. Cartographic Company 1942."; Catalogue record generated as part of a batch load.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Australia. Army. Survey Corps.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Exmouth Gulf, Western Australia [cartographic material].
, 1942 1st ed. "Printed by A.H.Q. Cartographic Company 1942."; Catalogue record generated as part of a batch load.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Australia. Army. Survey Corps.
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Clinicians' Perspectives on Pre-Anaesthetic Assessment and Their Attitudes Towards AI-Supported Models: Protocol for an International Survey of Anaesthesia Personnel. [PDF]
Acta Anaesthesiol ScandChristiansen CTG +10 more
europepmc +1 more source
Caledon Bay, Northern Territory [cartographic material].
, 1942 2nd ed. "Printed by A.H.Q. Cartographic Company 1942."; Catalogue record generated as part of a batch load.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Australia. Army. Survey Corps.
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source