Results 281 to 290 of about 15,304,814 (364)

Modified Delphi Consensus Guidelines for Pelvic Floor Botulinum Toxin Injection. [PDF]

Urogynecology (Phila)
Hufnagel DH, Torosis M, Ackerman AL.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Clinical practice in using corticosteroids and adjunctive sepsis therapies at the bedside among European ICUs: an ESICM-endorsed survey. [PDF]

Intensive Care Med Exp
David S, Leone M, Girardis M, Müller MM, Gavrilovic S, Domizi R, Damiani E, Martin-Loeches I, Ferrer R, Chousterman B, Russell L, ESICM “systemic inflammation, sepsis” (SIS) section.   +12 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Awareness of chemotherapy-induced nausea and vomiting and adherence to guidelines: results of a multinational and multicenter survey, part of the THRIVE program. [PDF]

Support Care Cancer
Caponero R, Enrico D, Giudice F, Ayoub JP, Lapointe N.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring clinician and patient perspectives on choice of general anaesthetic. A report of two U.S. surveys: an anesthesia clinician Multicenter Perioperative Outcomes Group survey and a patient Amazon Mechanical Turk survey. [PDF]

BJA Open
Holzer KJ, Hurwitz RM, Tellor Pennington BR, Politi MC, Vaughn MT, Chu L, Price A, Hicks M, Avidan MS, Kheterpal S.   +9 more
europepmc   +1 more source

Understanding Psychologists' Usage, Knowledge, and Attitudes Toward Digital Mental Health Solutions for Refugees and Migrants: Exploratory Cross-Sectional Survey in Sweden.

JMIR Hum Factors
Vernmark K, Geranmayeh A, Topooco N, Andersson G, Shahnavaz S.   +4 more
europepmc   +1 more source