Results 241 to 250 of about 1,617,498 (307)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Psychosocial Factors Surrounding Aesthetic Rhinoplasty: A Systematic Review. [PDF]

Plast Reconstr Surg Glob Open
Nagy KK, Cushman CJ, Selby M, Salter WZ, Hernandez EJ, Daniele E, MacKay BJ, Demke JC.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The CanCURE Survey: Gender-Based Differences in HIV Cure Research Priorities. [PDF]

J Pers Med
Lu J, Vulesevic B, Margolese S, Masching R, Tharao W, Cardinal C, Hedrich T, Mallais C, Dubé K, Cohen E, Chomont N, Costiniuk CT.   +11 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Bridging Organic Chemistry Teaching Laboratories and Real-World Research with Modern Computing and Spectroscopic Techniques. [PDF]

ACS Omega
Camp DM.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Virtual Visits in Pediatrics-Readiness, Barriers and Perceptions Among Healthcare Professionals: A Cross-Sectional Survey. [PDF]

Children (Basel)
Castro Garrido I, Simoneau T, Gaffin JM, Ibarzabal Arregi M, Gimeno Castillo M, Chaverri Reparaz CM, Fernandez-Montero A, Moreno-Galarraga L.   +7 more
europepmc   +1 more source

Enhancing clinical laboratory quality in Rwanda: addressing healthcare expectations and future fitness - insights from observations and perspectives of physicians and laboratory professionals. [PDF]

BMC Health Serv Res
Nzabahimana I, Namatovu F, Uwineza A, Rusanganwa V.   +3 more
europepmc   +1 more source