Results 241 to 250 of about 10,396,659 (347)

Doctors' job shifts between non-profit and for-profit healthcare organisations: evidence from a national panel of doctors. [PDF]

BMC Res Notes
Fadum EA, Bååthe F, Bringedal B, Rø KI, Hem E.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Review of Survey activities 2013: A multidisciplinary study of a geothermal reservoir below Thisted, Denmark [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2014
Hjuler, M.L., Vosgerau, H., Nielsen, C.M., Frykman, P., Kristensen, L., Mathiesen, A., Bidstrup, T., Nielsen, L.H.   +7 more
doaj  

Development of a core outcome set for the evaluation of shared decision-making interventions in healthcare: a study protocol. [PDF]

BMJ Open
Hoffmann C, Butterworth JE, Naye F, Smith M, Nyamapfene T, Lawday S, Avery K, Bekker H, Bravo P, Décary S, Edwards A, Elwyn G, Engelhardt EG, Franco JVA, Garvelink MM, Giguere AM, Härter M, Hoffmann T, Kienlin S, McCaffery K, Noordman J, Olling K, Perestelo-Pérez L, Pieterse AH, Scheibler F, Sepucha K, Ubbink D, Valentine KD, Volk RJ, Wehking F, Yoo SH, Bulbeck H, Cole AC, de Wit M, Finderup J, Geary K, Gunn CM, Hou WH, Housten AJ, Kim MJ, Norma M, Pacheco-Brousseau L, Snede L, Tian C, Toupin-April K, McNair AG.   +45 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Blood donation knowledge, attitudes, previous donation and student community engagement at Rajshahi University, Bangladesh: a cross-sectional study. [PDF]

BMJ Open
Ara MT, Alam MR, Rahman MM, Zahan MS, Hakim MA, Mika SM.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Wired for care: a cross-sectional survey protocol of health information technology, resilience and performance in Canadian long-term care homes. [PDF]

BMJ Open
Jaana M, Cruise D, Khalil T, Paré G, Tamim H.   +4 more
europepmc   +1 more source