Results 141 to 150 of about 8,796,658 (382)

“Survival of the Fittest” [PDF]

Nature, 1879
IN NATURE, vol. xix. p. 155, Mr. S. F. Clarke's observations on the cannibal habits so rapidly developed by the larvae of the New England salamanders are cited in illustration of the survival of the fittest. The fact that similar tendencies are invariably betrayed very early in life by theyoung of the common Mexican Axolotl (Siredon mexicanum), numbers
openaire   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Grafting of Nigral Tissue Hibernated with Tirilazad Mesylate and Glial Cell Line-Derived Neurotrophic Factor

Cell Transplantation, 2000
Transplantation of embryonic ventral mesencephalon is a potential therapy for patients with Parkinson's disease. As only around 5–10% of embryonic dopaminergic neurons survive grafting into the adult striatum, it is considered necessary to use multiple ...
Åsa Petersén, Oskar Hansson, Mia Emgård, Patrik Brundin   +3 more
doaj   +1 more source

The Survival of Primitive Implements, Materials and Methods in the Faroes and South Iceland [PDF]

, 1903
Nelson Annandale
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current Approaches

Cell Transplantation, 2000
Neural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3–20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that
Patrik Brundin, Jenny Karlsson, Mia Emgård, Gabriele S. Kaminski Schierle, Oskar Hansson, Åsa Petersén, Roger F. Castilho   +6 more
doaj   +1 more source

Long Survival in Mitral Stenosis [PDF]

, 1959
H. R. M. Johnson
openalex   +1 more source

Survival of the Likeliest?

PLoS Biology, 2007
This feature explores how the laws of thermodynamics to explain natural selection and life itself.
openaire   +5 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Strange Survivals: Some Chapters in the History of Man [PDF]

, 1892
Sabine Baring-Gould
openalex   +1 more source