Results 161 to 170 of about 6,664,577 (297)

Mortality reduction and survival extension in cardiovascular trials: why language matters. [PDF]

Open Heart
Tona F.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

First study on the survival and dispersal of captive-reared narrow-headed softshell turtles along the Yamuna River, India

Oryx
Arunima Singh, Shailendra Singh, Adarsh Kumar, Pawan Shantiprakash Pareek, Sreeparna Dutta   +4 more
doaj   +1 more source

Survival Modeling Using Deep Learning, Machine Learning, and Statistical Methods: A Comparative Analysis for Predicting Mortality After Hospital Admission. [PDF]

Health Data Sci
Wang Z, Lee JW, Chakraborty T, Ning Y, Liu M, Xie F, Ong MEH, Liu N.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of ovarian cancer immune cell profile identifies immunosuppressive states associated with adverse clinical attributes and survival times. [PDF]

PLoS One
Moscoso A, Mohammad Mirzaei N, Shahriyari L.   +2 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Turning the tide for sharks: Important Shark and Ray Areas

Oryx
Asia O. Armstrong, Amanda Batlle-Morera, Vanessa Bettcher Brito, Ryan Charles, Emiliano García-Rodríguez, Adriana Gonzalez-Pestana, Peter M. Kyne, Giuseppe Notarbartolo di Sciara, Marta D. Palacios, Christoph A. Rohner, Rima W. Jabado   +10 more
doaj   +1 more source

Influence of different therapy strategies in patients with myelodysplastic neoplasms (MDS) on overall survival with regard to different decades: data from the German MDS registry. [PDF]

Ann Hematol
Welsch J, Schulz F, Kasprzak A, Aul C, Götze KS, Nusch A, Lipke J, Parmentier S, Strupp C, Nachtkamp K, Kobbe G, Dietrich S, Gattermann N, Germing U.   +13 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source