Results 221 to 230 of about 3,992,788 (314)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

An IUCN Species Survival Commission Center for Species Survival on Behaviour Change

Oryx
João Neves, Isa Pinho, Edgar Ribeiro
doaj   +1 more source

Physical frailty is the most important predictor of early mortality in hospitalized patients with decompensated cirrhosis. [PDF]

Hepatol Commun
D'Arcangelo F, Vivian LM, Ferrarese A, Gambato M, Germani G, Senzolo M, Russo FP, Burra P, Burra P, Zanetto A.   +9 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Trifluridine/tipiracil and survival in mismatch repair-deficient metastatic colorectal cancer. [PDF]

Ther Adv Med Oncol
Chang PH, Huang WK, Su YL, Kuan FC, Hsieh JC, Hsu HC.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Indigenous knowledge programme cultural event, May 7, 1998 : Conference of the Parties IV, Bratislava, Slovakia

, 1998
Cultural Survival Canada
core  

Estimating Baseline Survival Function in the Proportional Hazards Model Under Monotone Hazards. [PDF]

J Stat Theory Pract
Wu Y, Chappell R.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Creation of the IUCN Species Survival Commission Gekkota Lizard Specialist Group

Oryx
Liliana Saboyá-Acosta, Thomas Ziegler, Andrea Echeverry-Alcendra, Jon Paul Rodríguez, Edgard Yerena   +4 more
doaj   +1 more source