Results 111 to 120 of about 2,712,400 (306)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Feature selection for classification of survival analysis in lymphoma cancer
, 2013 Survival analysis is known to have great potential for classifying clinical dataset and it has not been fully explored for classifying lymphoma cancer.
Omar, Norshafarina
core
Survivability Analysis of Networked Systems [PDF]
, 2006 Survivability is the ability of a system to continue operating despite the presence of abnormal events such as accidental failures and malicious intrusions. Ensuring system survivability has increased in importance as critical infrastructures have become heavily dependent on computers.
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Survival Analysis with Multivariate adaptive Regression Splines
, 2007 Multivariate adaptive regression splines (MARS) are a useful tool to identify linear and nonlinear effects and interactions between two covariates. In this dissertation a new proposal to model survival type data with MARS is introduced.
Kriner, Monika
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Lifestyle Influence on Mild Cognitive Impairment Progression: A Decision Tree Prediction Model Study
Neuropsychiatric Disease and TreatmentJiwen Hou,1,2,* Hua Jiang,1,* Yan Han,1 Rong Huang,1 Xiang Gao,1 Wei Feng,1 Zongjun Guo2 1Department of Geriatrics, Affiliated Hospital of Chengdu University, Chengdu, People’s Republic of China; 2Department of Geriatrics, Affiliated Hospital of ...
Hou J +6 more
doaj
The Cumulative Residual Entropy in Assessing the Duration of Unemployment
EkonometriaAim: The aim of the article was to use cumulative residual entropy (CRE) to assess the informational value of data on deregistration from the Poviat Labour Office in Szczecin (Poland) from 2007 to 2024. The events of declining cooperation with the labour
Beata Bieszk-Stolorz
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source