Results 111 to 120 of about 25,541,282 (305)

Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study

The World Journal of Men's Health
Purpose: Androgen signaling is associated with various secondary cancer, which could be promising for potential treatment using androgen deprivation therapy (ADT). This study investigated whether ADT use was associated with secondary cancers other than
Jae Heon Kim, Gi Hwan Bae, Jaehun Jung, Tae Il Noh   +3 more
doaj   +1 more source

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database

Frontiers in Immunology
BackgroundWhile simultaneous chemoradiotherapy remains the established therapeutic modality for patients afflicted with locally advanced esophageal cancer, the effectiveness of this radical approach falls short of the desired outcome.
Liangyun Xie, Liangyun Xie, Zhi Zhang
doaj   +1 more source

Computational Methods in Survival Analysis [PDF]

Survival analysis is widely used in the fields of medical science, pharmaceutics, reliability and financial engineering, and many others to analyze positive random phenomena defined by event occurrences of particular interest.
Kamakura, Toshinari
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Bayesian Survival Analysis Using Gene Expression [PDF]

, 2013
This research aims to compare and apply Bayesian models for patient survival using gene expression as explanatory variables. Three models were examined; the Weibull model, the Weibull mixture model and the Weibull cure model.
Thamrin, Sri Astuti
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Sensitivity models for missing covariates in the analysis of survival data from multiple surveys [PDF]

, 2007
Using individual patient data from five independent surveys, we evaluate regional variations in survival in cerebral palsy. The influence of four important variables measuring disability, which are only partially observed for many cases, are analysed ...
Hemming, Karla, Hutton, Jane
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The Cumulative Residual Entropy in Assessing the Duration of Unemployment

Ekonometria
Aim: The aim of the article was to use cumulative residual entropy (CRE) to assess the informational value of data on deregistration from the Poviat Labour Office in Szczecin (Poland) from 2007 to 2024. The events of declining cooperation with the labour
Beata Bieszk-Stolorz
doaj   +1 more source