Results 251 to 260 of about 28,926,907 (345)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies. [PDF]

Leukemia
Rodriguez L, Delhommeau F, Soussi T.
europepmc   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Model Validation for Survival Analysis by Smoothed Predictive Likelihood. [PDF]

Stat Med
Lu C, Putter H, Girondo MR, Goeman JJ.
europepmc   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Complications and Recurrence After Pelvic Exenteration for Gynecologic Malignancies: Survival Analysis From the COREPEX Study. [PDF]

Obstet Gynecol
Bizzarri N, Querleu D, Ricotta G, Giannarelli D, Cãpîlna ME, Domingo S, Chiantera V, Akıllı H, Cibula D, Novák Z, Zach D, Miranda A, Korompelis P, Chacon E, Zapardiel I, Lampe B, Svintsitskyi V, Matylevich O, van Ramshorst GH, Taskiran C, Demirkıran F, Lengyel T, Vizzielli G, Loverro M, Ferron G, Martinez A, Gauroy E, Ladanyi E, Kiss SL, Lago V, Montesinos-Albert M, Di Donna MC, Cucinella G, Ayhan A, Slama J, Rosta V, Salehi S, Muallem MZ, Kucukmetin A, Scambia G.   +39 more
europepmc   +1 more source

Cure Models in Survival Analysis

, 2018
Maïlis Amico, I. Keilegom
semanticscholar   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Survival analysis of time to quit attempt using data from the international tobacco control survey in Canada (2002-2014). [PDF]

Sci Rep
Yasmeen U, Thompson M.
europepmc   +1 more source