Results 111 to 120 of about 2,431,681 (314)

Individual patient data meta-analysis of survival data using Poisson regression models

BMC Medical Research Methodology, 2012
Background An Individual Patient Data (IPD) meta-analysis is often considered the gold-standard for synthesising survival data from clinical trials. An IPD meta-analysis can be achieved by either a two-stage or a one-stage approach, depending on whether ...
Crowther Michael J, Riley Richard D, Staessen Jan A, Wang Jiguang, Gueyffier Francois, Lambert Paul C   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Predicting Survival of Patients with Lung Cancer Using Improved Adaptive Neuro-Fuzzy Inference System

مجله انفورماتیک سلامت و زیست پزشکی, 2020
Introduction: Lung cancer is the main cause of mortality in both genders worldwide. This disease is caused by the uncontrollable growth and development of cells in both or one of the lungs. Although the early diagnosis of this cancer is not an easy task,
Ommolbanin Abbasi, Mohammadreza Ramezanpour, Reihaneh Khorsand   +2 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Summarizing and communicating on survival data according to the audience: a tutorial on different measures illustrated with population-based cancer registry data [PDF]

, 2019
Aurélien Belot, Aminata Ndiaye, Miguel-Angel Luque-Fernandez, Dimitra-Kleio Kipourou, Camille Maringe, Francisco Javier Rubio, Bernard Rachet Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and ...
Rachet B, Luque-Fernandez MA, Kipourou DK, Rubio FJ, Belot A, Ndiaye A, Maringe C   +6 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Figure 3 Survival Data

, 2018
Survival Data Figure 3: Each row represents survival data for a replicate vial. Columns: vial—unique identifier; EggDate—Date of egg collection; Time—Time of setup; pupadata—day of first pupa; ecloseday—day of first eclosion; sex—sex; totals—number of ...
Buchanan, Justin L., Meiklejohn, Colin D., Montooth, Kristi L., Justin L. Buchanan (7057268), Colin D. Meiklejohn (7913414), Kristi L. Montooth (7913417)   +5 more
core   +1 more source

Pseudo-observations for bivariate survival data

Biometrics
ABSTRACT The pseudo-observations approach has been gaining popularity as a method to estimate covariate effects on censored survival data. It is used regularly to estimate covariate effects on quantities such as survival probabilities, restricted mean life, cumulative incidence, and others.
Yael Travis-Lumer, Micha Mandel, Rebecca A Betensky   +2 more
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Predicting the short and long term effects of food price inflation, armed conflicts, and climate variability on global acute malnutrition in Somalia

Journal of Health, Population and Nutrition
Background Malnutrition poses a substantial challenge in Somalia, impacting approximately 1.8 million children. This critical issue is exacerbated by a multifaceted interplay of factors.
Jama Mohamed, Mukhtar Jibril Abdi, Ahmed Ismail Mohamed, Mohamed Aden Muhumed, Barkhad Aden Abdeeq, Abdinasir Ali Abdi, Mohamed Mussa Abdilahi, Dahir Abdi Ali   +7 more
doaj   +1 more source