Results 231 to 240 of about 3,364,430 (292)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review). [PDF]

Int J Mol Med
Tang F, Liu D, Zhu SC, Zhou HM, Qiu XW.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Prospective study of fibrosis in the lung endpoints (PROFILE): characteristics of an incident cohort of patients with idiopathic pulmonary fibrosis. [PDF]

BMJ Open Respir Res
Maher TM, Jenkins GR, Saini G, Braybrooke R, Johnson SR, Chua F, Lukey PT, Simpson JK, Allen RJ, Wain LV, Fahy WA, Molyneaux PL, Stewart I.   +12 more
europepmc   +1 more source

Endothelial MLKL Inhibition Reduces Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice. [PDF]

J Cell Mol Med
Ning J, Deng J, Sang Y, Qiao L.
europepmc   +1 more source

Non-Transplantable Recurrence After Initial Liver Resection of Hepatocellular Carcinoma: A Narrative Review. [PDF]

Cancers (Basel)
Malkawi D, Ziogas IA, Gleisner AL, Schulick RD, Moris DP.   +4 more
europepmc   +1 more source

Considerations for Estimating Causal Effects of Informatively Timed Treatments. [PDF]

Epidemiology
Oganisian A.
europepmc   +1 more source