Results 231 to 240 of about 174,614,231 (302)

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

NOR1 loss relates to inflammation and biological ageing in multiple sclerosis motor cortex. [PDF]

Brain Commun
Unlu Kobya B, Avery A, DeLuca G, Pansieri J.   +3 more
europepmc   +1 more source

Survival motor neuron SMN1 and SMN2 gene promoters: identical sequences and differential expression in neurons and non-neuronal cells

European Journal of Human Genetics, 2004
B. Boda, C. Mas, C. Giudicelli, V. Népote, F. Guimiot, B. Levacher, A. Zvara, M. Santha, I. Legall, M. Simonneau   +9 more
semanticscholar   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

Tofersen Treatment in <i>SOD1</i>-ALS: Real-World Evidence from a Retrospective Multicenter Study in France (FORSLA Study). [PDF]

Mayo Clin Proc Innov Qual Outcomes
Erazo D, Hesters A, Bruneteau G, De La Cruz E, Bernard E, Grapperon AM, Le Masson G, Cintas P, Soriani MH, Guy N, Cassereau J, Camdessanché JP, Genestet S, Corcia P, Pittion S, Danel V, Filliatre M, Choumert A, Jacquin-Piques A, Salachas F, Esselin F, Bohic A, Lautrette G, Attarian S, Catteau J, Guissart C, Vincent MC, Mouzat K, Temple M, Vourc'h P, Couratier P.   +30 more
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients. [PDF]

Front Neurol
Couto CM, de Melo Queiroz E, da Cunha MC, Santos SCL, Ferreira AR, Nascimento OJM.   +5 more
europepmc   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Spinal muscular atrophy with five <i>SMN2</i> copies: Phenotypic heterogeneity and implications for newborn screening and treatment decisions. [PDF]

Front Neurol
Parmova O, Adamova B.
europepmc   +1 more source