Results 141 to 150 of about 4,464,251 (309)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Deep Learning for Survival Outcomes

, 2019
This manuscripts develops a new class of deep learning algorithms for outcomes that are potentially censored. To account for censoring, the unobservable loss function used in the absence of censoring is replaced by a censoring unbiased transformation. The resulting class of algorithms can be used to estimate both survival probabilities and restricted ...
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prognostic significance of the C-reactive protein-to-lymphocyte ratio in patients with cancers

Frontiers in Oncology
BackgroundThe C-reactive protein-to-lymphocyte ratio (CLR), a novel inflammation-based biomarker, has been reported to be associated with prognosis in various cancers. However, the prognostic significance of CLR remains controversial.
Xiaohui Liu, Shaobo Zhang, Yi Liu
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Deep learning prediction of overall survival in glioblastoma patients using pre-chemoradiotherapy MRI and clinical data

Frontiers in Radiology
PurposeGlioblastoma (GBM) exhibits variable treatment response and patients shown a median survival of 15 months. A major challenge lies in the difficulty of reliably assessing treatment response at an early stage, as it can usually only be evaluated on ...
Noémie N. Moreau, Noémie N. Moreau, Alexis Desmonts, Alexis Desmonts, Alexis Desmonts, Cyril Jaudet, Thomas Leleu, Alexandre G. Leclercq, Alexandre G. Leclercq, Alexandre G. Leclercq, Carole Brunaud, Dinu Stefan, Samuel Valable, Alexis Lechervy, Aurélien Corroyer-Dulmont, Aurélien Corroyer-Dulmont, Aurélien Corroyer-Dulmont   +16 more
doaj   +1 more source

Metabolic Syndrome and Survival Outcomes in Endometrial Cancer

Cureus
Menopause, through attributable estrogen level decline and the corresponding increase in circulating androgens, significantly elevates a woman's risk for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular disease.
Marin, Alina-Gabriela, Filipescu, Alexandru, Vladareanu, Radu, Petca, Aida   +3 more
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Retinal Microstructural Features for Estimating Survival Outcome in Glioblastoma Patients

Excel data and Prism graphs generated in a study investigating predictive potential of retinal features from OCT/OCTA in predicting survival outcome in patients with ...
Liu, Yin Allison, Smith, Rebekah
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source