Results 121 to 130 of about 561,319 (304)
Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]
, 2019 The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S. +9 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
A novel necroptosis signature for predicting survival in lung adenocarcinoma.
BMC medical genomics, 2023 To explore the necroptosis-related genes (NRGs) signature and its predictive values in lung adenocarcinoma (LUAD).The training cohort consisted of tumor samples from The Cancer Genome Atlas, and the validation set comprised data from the Gene Expression Omnibus. Univariate and multivariate Cox regression analyses were applied to identify the prognostic
Zang, Kui +4 more
openaire +2 more sources
A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma
BMC Cancer, 2018 Background Endometrial cancer (UCEC) is a complex malignant tumor characterized by both genetic level and clinical trial. Patients with UCEC exhibit the similar clinical features, however, they have distinct outcomes due to molecular heterogeneity.
Meng Zhou +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The aim of the current study was to identify potential prognostic long non-coding RNA (lncRNA) biomarkers for predicting survival in patients with hepatocellular carcinoma (HCC) using The Cancer Genome Atlas (TCGA) dataset and ...
Xiwen Liao +15 more
doaj +1 more source
Identification of an alternative splicing signature as an independent factor in colon cancer
BMC Cancer, 2020 Background Colon cancer is a common malignant tumor with a poor prognosis. Abnormal alternative splicing (AS) events played a part in the occurrence and metastasis of the tumor.
Haitao Chen, Jun Luo, Jianchun Guo
doaj +1 more source
An integrative analysis of cancer gene expression studies using Bayesian latent factor modeling
, 2010 We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies.
Chen, Julia Ling-Yu +3 more
core +1 more source
Integrative analysis of the colorectal cancer proteome : potential clinical impact [PDF]
, 2016 Peer ...
Alnabulsi, Abdo, Murray, Graeme I.
core +2 more sources