Results 111 to 120 of about 60,299 (235)

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Polyploid superficial cells that maintain the urothelial barrier are produced via incomplete cytokinesis and endoreplication [PDF]

, 2018
Summary: The urothelium is an epithelia barrier lined by a luminal layer of binucleated, octoploid, superficial cells. Superficial cells are critical for production and transport of uroplakins, a family of proteins that assemble into a waterproof ...
Batourina, Ekatherina, Canman, Julie C, Dan, Hanbin, George, Christopher D, Liu, Chang, Mendelsohn, Cathy Lee, Mysorekar, Indira U, Schneider, Kerry, Souza, Spenser, Swayne, Theresa, Tate, Tiffany, Wang, Jia, Wiessner, Gregory, Zhuravlev, Yelena   +13 more
core   +3 more sources

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal, Muhammad Shahbaz, Asfa Perween, Muhammad Hammad ul Hassan, Hammad Naeem, Zubda Shahid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Tadesse FentaYehuala, Samy Selim, Ehab M. Mostafa   +14 more
wiley   +1 more source

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. [PDF]

, 2018
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis.
Arcidiacono, P, Blaydon, DC, Brooke, MA, Chikh, A, Delaney, PJ, Kelsell, DP, Ng, K-E, Tinker, A, Webb, CM, Zhou, H   +9 more
core   +2 more sources

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

Expression and Clinical Significance of Antiapoptotic Gene (Survivin) in NB4 and Acute Promyelocytic Leukemia Cells

The Scientific World Journal, 2012
To study survivin gene expression in APL cells and to explore its correlation with clinical manifestations. PML/RARα and survivin mRNA expression were analysed using RT-PCR.
Jun Xue, Xiao-Jing Xie, Mao-Fang Lin
doaj   +1 more source

the moon cuts like pye, but not cherry [PDF]

, 2017
In our work we prefer asking questions to telling stories. As a means to invigorate and cross-examine our current reality, our hystories, and our definitions of ‘self’ we peer through a disparate lens cultivating pockets: compartments longing to be ...
collins, jacqueline Avery
core   +1 more source

Survivin--a universal tumor antigen.

Histology and histopathology, 2002
Tumor-associated antigens recognized by cellular effectors of the immune system are potential targets for antigen-specific cancer immunotherapy. These antigens are classified as tissue (melanocyte)-specific proteins, cancer-testis antigens (proteins expressed in normal testis and various cancers), tumor-specific peptides derived from mutations in tumor
Andersen, M.H., thor Straten, P.
openaire   +3 more sources

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis

Cell Reports, 2016
Summary: A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. Survivin is highly expressed during embryogenesis and in several cancer types, but little is known
Eva Martini, Nadine Wittkopf, Claudia Günther, Moritz Leppkes, Hitoshi Okada, Alastair J. Watson, Eva Podstawa, Ingo Backert, Kerstin Amann, Markus F. Neurath, Christoph Becker   +10 more
doaj   +1 more source