Results 121 to 130 of about 59,431 (239)

Expression and Clinical Significance of Antiapoptotic Gene (Survivin) in NB4 and Acute Promyelocytic Leukemia Cells

The Scientific World Journal, 2012
To study survivin gene expression in APL cells and to explore its correlation with clinical manifestations. PML/RARα and survivin mRNA expression were analysed using RT-PCR.
Jun Xue, Xiao-Jing Xie, Mao-Fang Lin
doaj   +1 more source

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. [PDF]

, 2018
Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC).
Addya, Sankar, Bhardwaj, Anshul, Birbe, Ruth, Chellappagounder, Thangavel, Den, Robert B., Dicker, Adam P., Ertel, Adam, Ettickan, Boopathi, Haber, Alex, Knudsen, Karen E., Liu, Yi, McNair, Christopher, Perepelyuk, Maryna, Salvino, Joseph M., Shoyele, Sunday   +14 more
core   +1 more source

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Med Research, Volume 2, Issue 1, Page 157-180, March 2026.
The graphical abstract outlines the progressive development and impact of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Technological Evolution illustrates the transition from brachytherapy with single‐dose, LDR/HDR schedules to fractionated radiotherapy, three‐dimensional conformal radiotherapy (3DCRT) and Gamma Knife ...
Jing Zhang, Wenhao Xu, Weiqing Lu, Yingxuan Lin, Luoxi He, Zonglin Lv, Yiliyaer Nuerrula, Zouting, Zhen Zhang, Hailiang Zhang, Xuejun Ma   +10 more
wiley   +1 more source

Exosomal survivin facilitates vesicle internalization

Oncotarget, 2018
Survivin, a member of the inhibitor of apoptosis (IAP) protein family plays a significant role in cell fate and function. It is significantly overexpressed in tumor cells and has been identified in most cancer cell types. A novel extracellular population has recently been identified and its function is still unknown. Emerging evidence continues to shed
Gonda, Amber, Kabagwira, Janviere, Senthil, Girish N., Ferguson Bennit, Heather R., Neidigh, Jonathan W., Khan, Salma, Wall, Nathan R.   +6 more
openaire   +3 more sources

The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Dysregulated JAK/STAT signaling and related genetic mutations are strongly associated with cancer progression, including promoting tumor proliferation, suppressing apoptosis, inducing immune suppression, participating in drug resistance. Based on the function of the JAK/STAT pathway in disease pathogenesis, numerous agents targeting the JAK/STAT ...
Yixing Liao, Qi Wei, Hongjun Song, Hao Zeng, Chang Qi, Yunchang Meng, Yuanyuan Zhang, Yuanyuan Zhang, Weimin Li, Yalun Li, Panwen Tian   +10 more
wiley   +1 more source

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis

Cell Reports, 2016
Summary: A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. Survivin is highly expressed during embryogenesis and in several cancer types, but little is known
Eva Martini, Nadine Wittkopf, Claudia Günther, Moritz Leppkes, Hitoshi Okada, Alastair J. Watson, Eva Podstawa, Ingo Backert, Kerstin Amann, Markus F. Neurath, Christoph Becker   +10 more
doaj   +1 more source

Multidrug resistance of non-adherent cancer cells [PDF]

, 2010
Metastases are the cause of 90% of human cancer deaths. Cancer in _situ_ can usually be effectively removed by surgery. Once cancer cells disseminate from the original site and start to circulate in blood, lymph, or other body fluids, the disease becomes
Guangming Liu, Navneet Singh, Subhas Chakrabarty   +2 more
core   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Survivin induces defects in apoptosis in eosinophils in intestine with food allergy

Innate Immunity, 2019
Survivin is an anti-apoptosis protein that may be associated with the development of eosinophilia; the latter is associated with the pathogenesis of many immune disorders.
Han Gao, Bai-Sui Feng, Jiang-Qi Liu, Li-Hua Mo, Xiao-Rui Geng, Yuan Xiao, Yuan-Yi Zhang, Jing-Yi Hong, Zhan-ju Liu, Zhi-Gang Liu, Yisheng Feng, Ping-Chang Yang   +11 more
doaj   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source