Results 111 to 120 of about 59,883 (231)

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1487-1505, May 2026.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

BMC Neuroscience, 2010
Background Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein.
Eisch Amelia, Cremer Harold, Reumers Veerle, Baekelandt Veerle, Moons Michaël, Antonucci Flavia, Cremer Jonathan, DeVriese Astrid, D'Hooge Rudi, Balschun Detlef, Ahmed Tariq, Coremans Vanessa, Lagace Diane, Janssens Tom, Bozzi Yuri, Caleo Matteo, Conway Edward M   +16 more
doaj   +1 more source

Zebularine Boosts Imatinib Efficacy in Cells of Colorectal Cancer via Wnt‐Survivin‐P‐Glycoprotein Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
The combination of IM and ZEB showed a promising combination in management of CRC by inducing oxidative stress, promoting apoptosis, and modulating critical genes involved in metastasis and apoptosis. ABSTRACT Colorectal cancer (CRC) remains one of the leading causes of cancer mortality, with a poor survival rate of less than 15%.
Yasmin M. Attia, Abeer Elkhoely, Fatma M. Abdelwahed, Samia A. Shouman, Mervat M. Omran   +4 more
wiley   +1 more source

the moon cuts like pye, but not cherry [PDF]

, 2017
In our work we prefer asking questions to telling stories. As a means to invigorate and cross-examine our current reality, our hystories, and our definitions of ‘self’ we peer through a disparate lens cultivating pockets: compartments longing to be ...
collins, jacqueline Avery
core   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Survivin蛋白的原核表达及在肿瘤诊断中的初步应用研究

Zhongguo shiyan zhenduanxue, 2007
目的实现Survivin蛋白在大肠杆菌BL21中的可溶性表达,建立基于Survivin蛋白的Survivin抗体检测方法,为survivin的深入研究及肿瘤的早期诊断奠定基础。方法从食管癌细胞Eca109中提取RNA,经RT-PCR扩增,克隆出Survivin基因;用PCR将Survivin克隆至载体pET32a（+）;用双酶切和DNA测序技术对构建的载体进行鉴定;IPTG诱导Survivin蛋白表达,用镍离子亲和层析纯化,ELISA及Western blot鉴定 ...
郭建巍, 王小平, 马骢, 王珍光, 蒋学兵, 刘敏   +5 more
doaj  

Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients

Journal of Translational Medicine, 2009
Background We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B.
Yamaguchi Akira, Miyazaki Akihiro, Idenoue Satomi, Hirohashi Yoshihiko, Torigoe Toshihiko, Kobayashi Jun-ichi, Hiratsuka Hiroyoshi, Sato Noriyuki   +7 more
doaj   +1 more source

Antagonizing CD105 enhances radiation sensitivity in prostate cancer. [PDF]

, 2018
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery.
Andres, Allen, Angara, Bryan, Bhowmick, Neil A, Duong, Frank, Gottlieb, Roberta, Haldar, Subhash, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Zumsteg, Zachary S   +9 more
core   +1 more source

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]

, 2009
BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Barth, Susanne, Breitling, Rainer, Cinatl jr., Jindrich, Cinatl, Jaroslav, Cinatl, Jindrich, Doerr, Hans W., Hinsch, Nora, Klassert, Denise, Mayer, Bernd, Michaelis, Martin, Suhan, Tatyana   +10 more
core   +6 more sources

The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

Cellular Physiology and Biochemistry, 2015
Background/Aims: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We investigated the effects of YM155, a small molecule inhibitor of survivin expression, on the radiosensitivity of human non ...
Songliu Hu, Songbin Fu, Xiangying Xu, Lin Chen, Jianyu Xu, Bin Li, Yuanyuan Qu, Hongyang Yu, Shan Lu, Wenxin Li   +9 more
doaj   +1 more source