Results 91 to 100 of about 506,209 (297)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Alternative reporting options for sexual assault: Perspectives of victim-survivors

, 2023
Anonymous reporting tools for sexual assault contribute to gathering intelligence, reducing crime, increasing reporting and supporting survivors. This article examines victimsurvivors’ knowledge of and experiences using alternative reporting options ...
Rachel Loney-Howes (10135031), Sophie Hindes (18034117), Nicola Henry (18028144), Georgina Heydon (18031105)   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Initial calf circumference predicts poor disability outcomes in patients with stroke

The Journal of Nutrition, Health and Aging
Background: Calf circumference (CC), which is easy to measure and noninvasive, may be a predictor of functional outcome in patients with acute stroke. However, the association between CC and long-term functional outcome is unclear.
Yoichi Sato, Takafumi Abe, Yosuke Kimura, Shu Tanaka, Kazuki Okuda, Ayaki Shirahata, Kenta Yamamoto, Masafumi Nozoe   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Effectiveness of rehabilitation dose heterogeneity for improving functional outcomes of patients with acute stroke: a nationwide observational study

Scientific Reports
To examine heterogeneity in the impact of increased early rehabilitation intensity and to identify which ischemic stroke patients benefit most. We analysed 39,140 propensity score-matched ischemic stroke patients using Diagnosis Procedure Combination ...
Takuaki Tani, Masashi Kanai, Masatoshi Kamada, Kazushige Ide, Kiyohide Fushimi   +4 more
doaj   +1 more source

Deinstitutionalization as Reparative Justice: A Commentary on the Guidelines on Deinstitutionalization, including in Emergencies

Laws
In this paper, I argue that the Committee on the Rights of Persons with Disabilities Guidelines on Deinstitutionalization, Including in Emergencies function as an instrument and template for reparative justice towards persons still in institutions and ...
Tina Minkowitz
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Baseline peak systolic blood pressure/left ventricular end-systolic volume index (sBP/LVESVI) in survivors and non-survivors

, 2011
Baseline sBP/LVESVI was not significantly different between survivors and non-survivors. Change in sBP/LVESVI from baseline at the point of maximum cardiac output response.
Eugene Bunnell (51074), Barry Milcarek (51076), Joseph E Parrillo (51077), Anand Kumar (24122), Amjad Ali (51075), Elizabeth Schupp (51073)   +5 more
core   +1 more source