Results 51 to 60 of about 6,240,497 (308)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Incorporating Dynamic Factors in Geological Hazard Risk Assessment: Integrating InSAR Deformation and Rainfall Conditions

Atmosphere
Geological hazards, particularly in mountainous regions, represent significant threats to life, property, and the environment. In this study, we focus on Luoping County, Yunnan Province, China, employing SBAS-InSAR technology to monitor surface ...
Hui Wang, Jieyong Zhu, Likun Chen, Haohan Shi   +3 more
doaj   +1 more source

An Evaluation of the World Bank Group’s Contributions

, 2021
More than a decade has passed since the global economic and financial crisis rocked the world. A clear lesson that emerged from it was the importance of identifying and addressing country-specific vulnerabilities
Independent Evaluation Group
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Performance Evaluation of Newly Developed Korean Antimicrobial Susceptibility Testing Panels for MicroScan System Using Clinical Isolates from Teaching Hospitals in Korea

Annals of Clinical Microbiology, 2019
Background: Antimicrobial resistant continues to pose a threat to public health. Therefore, rapid and accurate antimicrobial susceptibility testing is very important.
Da Young Kang, Jun Sung Hong, Byeol Yi Park, Dokyun Kim, Hyukmin Lee, Seok Hoon Jeong   +5 more
doaj   +1 more source

Annual corporate evaluation report 2000 [PDF]

, 2000
French version available in IDRC Digital Library: Rapport annuel sur l'évaluation 2000The Annual Corporate Evaluation (ACE) Report is an element of the Centre's performance monitoring and reporting system.
IDRC. Evaluation Unit
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Susceptibility analysis of geological hazards based on the random forest weighted information value model: A case study of Shidian County,Yunnan Province

Zhongguo dizhi zaihai yu fangzhi xuebao
Traditional information value models for evaluating geological hazard susceptibility typically involve simply summing the information values of various evaluation factors, without considering the differences in weight among these factors. This can affect
Cheng HUANG, Xiangsheng YAN, Hongbo MEI, Cuiqiong ZHOU, Ge HUANG   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source