Results 71 to 80 of about 406,650 (268)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Susceptibility Evaluation to Fire Blight and Genome-Wide Associations within a Collection of Asturian Apple Accessions. [PDF]

Plants (Basel), 2023
García-Fernández B, Dolcet-Sanjuan R, Micheletti D, Antón-Díaz MJ, Solsona C, Fernández M, Abad X, Dapena E.   +7 more
europepmc   +1 more source

Genetic Evaluation for Rifampicin-susceptibility of Mycobacterium tuberculosis

Journal of the Japanese Association for Infectious Diseases, 1997
We evaluated the relationship between rifampicin (RFP)-susceptibility and genetic alterations in rpoB gene of clinically isolated Mycobacterium tuberculosis strains, collected from different geographic locations within Japan. Alterations in rpoB gene were detected by PCR-direct sequencing analysis, and the minimum inhibitory concentrations (MICs) of ...
OHNO, Hideaki, KOGA, Hironobu, OGAWA, Kazuhiko, SASAKI, Eisuke, Yang, BING, YANAGIHARA, Katsunori, YAMAMOTO, Yoshihiro, MAESAKI, Shigefumi, HIRAKATA, Yoichi, TOMONO, Kazunori, TASHIRO, Takayoshi, KOHNO, Shigeru   +11 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Landslide Susceptibility Evaluation Based on Potential Disaster Identification and Ensemble Learning. [PDF]

Int J Environ Res Public Health, 2022
Wang X, Zhang X, Bi J, Zhang X, Deng S, Liu Z, Wang L, Guo H.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Landslide Susceptibility Evaluation of Machine Learning Based on Information Volume and Frequency Ratio: A Case Study of Weixin County, China. [PDF]

Sensors (Basel), 2023
He W, Chen G, Zhao J, Lin Y, Qin B, Yao W, Cao Q.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Classification optimization of geological hazard susceptibility evaluation factors based on AIFFC algorithm

Zhongguo dizhi zaihai yu fangzhi xuebao
This paper addresses the issue of uncertainty in the grading of geological hazard susceptibility evaluation factors and introduces the adaptive expansion factor fuzzy coverage grading method (AIFFC) to optimize the grading of geological hazard ...
Bin CHEN, Yingyi LI, Lianzhi ZHANG, Tianqiang QU, Na WEI, Ning LIU, Chunlin HUANG   +6 more
doaj   +1 more source