Results 71 to 80 of about 5,963,630 (346)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Thermokarst hazards susceptibility mapping on the Qinghai-Tibet plateau based on a collaborative IV-machine learning architecture

Geocarto International
Accelerating climate change intensifies permafrost degradation and thermokarst hazards on the Qinghai-Tibet Plateau (QTP), threatening ecosystems and infrastructure.
Tiantian Li, Wenhui Liu, Qiong Li, Hairui Liu, Sha Yang, Wei Li, Qing Li, Bingnan Luo, Jianqiang Zhang, Renjie He   +9 more
doaj   +1 more source

Landslide susceptibility mapping

, 2021
Due to privacy, the data used is not public. The code of this manuscript is available.
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Application of Hierarchical Multicriteria to Mass Movement Susceptibility along the Southern Escarpment of the Bamileke Plateau (West – Cameroon) [PDF]

Revue Hybrides
Mass movements are natural phenomena that cause the most damage in the West Cameroon Highlands (WCH). The severity of this damage is linked to the essentially random nature of these mass movements.
Raoul Merlin NDONBOU, David Guimolaire NKOUATHIO, Ghislain ZANGMO TEFOGOUM, Christian Suh GUEDJEO, Kan Jean Kouame   +4 more
doaj  

ON THE EFFECT OF DEM QUALITY FOR LANDSLIDE SUSCEPTIBILITY MAPPING

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2022
Abstract. Generating precise and up-to-date landslide susceptibility maps (LSMs) in landslide-prone areas is important to identify hazard potential in the future. The data quality and the method selection affect the accuracy of the LSMs. In this context, the accuracy and precision of the digital elevation models (DEMs) used as input are among the most ...
G. Karakas, G. Karakas, S. Kocaman, S. Kocaman, C. Gokceoglu   +4 more
openaire   +6 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reducing Streaking Artifacts in Quantitative Susceptibility Mapping [PDF]

SIAM Journal on Imaging Sciences, 2017
It is well known that reconstruction algorithms in quantitative susceptibility mapping often contain streaking artifacts. These are nondesirable objects that contaminate the image, and the possibility of removing or at least reducing them has a great practical interest. In [J. K. Choi, H. S. Park, S. Wang, Y. Wang, and J. K. Seo, SIAM J.
Benjamín Palacios, Gunther Uhlmann, Yiran Wang 0003   +2 more
openaire   +5 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Green Map Flushing Meadow Queens NY

, 2005
A map of Flushing Meadows Corona Park in Queens, NY, site of two world fairs (1939 and 1964) currently home to a number of recreation facilities and green space.
Green Map System (Firm)
core   +1 more source