Results 91 to 100 of about 5,963,630 (346)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Quantitative Susceptibility Mapping in Parkinson's Disease

PLOS ONE, 2016
Quantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD). However, the findings in other subcortical deep gray matter nuclei are converse and the sensitivity of QSM and R2* for morphological changes and their ...
Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jürgen Rainer Reichenbach, Reinhold Schmidt, Petra Schwingenschuh   +16 more
openaire   +4 more sources

Landslide susceptibility map of the Salem east and Salem west quadrangles

, 1996
plate 1. Liquefaction susceptibility map of the Salem east and Salem west quadrangles, Marion and Polk counties, Oregon -- plate 2. Amplication susceptibility map of the Salem east and Salem west quadrangles, Marion and Polk counties, Oregon -- plate 3 ...

core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Shallow landslide susceptibility map at a regional scale (Asturias, NW Spain). A heuristic-driven approach

Journal of Maps
The study area (Asturias, NW Spain) is a mountainous region extending over 10,000 km2, where shallow landslides triggered after heavy rainfall episodes are very frequent and pose a major threat and hazard to infrastructure and human populations, causing ...
Rosana Menéndez-Duarte, Jorge Marquínez, Daniel Vázquez-Tarrío, Francisco José Fernández   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Shallow-Water Submarine Landslide Susceptibility Map: The Example in a Sector of Capo d’Orlando Continental Margin (Southern Tyrrhenian Sea)

Journal of Marine Science and Engineering
Active continental margins, generally characterized by narrow shelves incised by canyons, are pervasively shaped by submarine landslides that can occur near coastal areas.
Elena Scacchia, Daniele Casalbore, Fabiano Gamberi, Daniele Spatola, Marco Bianchini, Francesco Latino Chiocci   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Genetic Mapping of Myopia Susceptibility Loci

Investigative Opthalmology & Visual Science, 2007
Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin cohort, linkage to these chromosomal regions ...
Maria, Schäche, Andrea J, Richardson, Kelly K, Pertile, Mohamed, Dirani, Katrina, Scurrah, Paul N, Baird   +5 more
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source