Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
A Rare Case of Methicillin-Susceptible Staphylococcus aureus Catheter-Related Bloodstream Infection Complicated by Acute Bacterial Meningitis and Refractory Septic Shock in Morocco: A Case Report. [PDF]
CureusBenoumrhar Y +4 more
europepmc +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Rice Genotype-Dependent Phyllosphere Microbiome Assembly and Isolation of Antagonistic <i>Burkholderia</i> for Sheath Blight Biocontrol. [PDF]
Int J Mol SciDanso Ofori A +9 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Family-wise resistance to infectious salmon anemia suggests that early systemic recognition protects against disease but not viral transcription. [PDF]
Front ImmunolJohnston AE +5 more
europepmc +1 more source
Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton +4 more
wiley +1 more source
Reply to McArdle and Austin, "Further detail required to assess additional evidence on agreement between VITEK 2 and broth microdilution piperacillin/tazobactam testing in cephalosporin resistant Enterobacterales". [PDF]
J Clin MicrobiolRichter SS, MacVane SH.
europepmc +1 more source
Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi +6 more
wiley +1 more source
A simplified MALDI-TOF MS method for rapid fluconazole susceptibility testing in <i>Candida</i> species. [PDF]
J Med MicrobiolLegabão BC +5 more
europepmc +1 more source