Results 121 to 130 of about 1,529,706 (313)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
High Vancomycin MIC and Complicated Methicillin-Susceptible Staphylococcus aureus Bacteremia [PDF]
, 2011 We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest.
Rodríguez Otero, J. +6 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Simulating a latent susceptible pool to examine the impact on cardiovascular mortality [PDF]
, 2012 The health effects of cold and hot temperatures are strongest in the frail and elderly. A large number of deaths in this "susceptible pool" after heat waves and cold snaps can cause mortality displacement, where an immediate increase in mortality is ...
Barnett, Adrian G. +3 more
core
, 2018 Time-lapse images of spread of T7 phage epidemics in Escherichia coli spatially structured populations over 48 hours.
Nick Barton (363978) +7 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Modeling the Transmission Dynamics of HIV/AIDS epidemics: an introduction and a review.
Journal of Infection in Developing Countries, 2010 Introduction: One of the greatest causes of morbidity and mortality in the Sub-Saharan Africa, particularly among young adults, is HIV/AIDS. Many mathematical models have been suggested for describing the epidemiology as well as the epidemiological ...
Onoja Matthew Akpa +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
MODEL SUSCEPTIBLE EXPOSED INFECTED RECOVERED SUSCEPTIBLE ( SEIRS ) [PDF]
, 2015 Abstrak. Penyakit menular disebabkan oleh virus atau bakteri. Individu sehat ( susceptible ) yang terkena virus atau bakteri tersebut dapat menunjukkan ( exposed ) gejala-gejala seperti demam, pusing, dan batuk.
Kristianto, Edwin
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source