Results 101 to 110 of about 1,529,706 (313)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Post-partum MMR immunisation rates in rubella-susceptible antenatal women [PDF]
, 2013 Rubella, an insignificant viral disease of childhood, can have devastating effects on the fetus if infection is acquired during pregnancy. An immunisation programme was established in the UK in the 1970s, with the monitoring of pregnant women for rubella
Gray, Debra +4 more
core +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Frontiers in Plant ScienceMaize is one of the most versatile and commercially produced crops used for food, feed, fodder, ethanol, oil, and industrial raw materials. Maize is affected by various diseases, but among these, maydis leaf blight (MLB) is one of the most serious ...
Bhupender Kumar +15 more
doaj +1 more source
Tanggap Genotipe Kacang Tanah Terhadap Penyakit Bercak Daun Cercospora dan Karat Daun Puccinia
Jurnal Fitopatologi Indonesia, 2016 Leaf spot and rust are two important diseases on groundnut. Both diseases are frequently found at the same time that influence the growth and reduce the yield of groundnut.
Alfi Inayati, Eriyanto Yusnawan
doaj +1 more source
Achieves of Scientific Research Epidemiological Models of Susceptible Infectious Recovered and Susceptible Infectious Susceptible Numbers [PDF]
, 2020 The objective of this paper is to investigate and compare the role of susceptible infectious recovered (SIR) and susceptible infectious susceptible (SIS) epidemic models.
S Balamuralitharan
core
Antibiotic non-susceptible patterns. [PDF]
, 2016 Antibiotic non-susceptible patterns.
Chih-Cheng Lai (533198) +7 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source