Results 151 to 160 of about 1,124,038 (359)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

NASOPHARYNGEAL SPECIMEN COLLECTION FROM SUSPECTED COVID-19 CASES, MAKING THE PROCEDURE SAFE

, 2021
Sohail Aslam, Syed Bukhari, Adnan Asghar, Naeem Riaz, Iftekhar Yousaf, Sana Muhammad Sadiq, Muhammad Fahd Waseem   +6 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

AB118. SOH23ABS_041. The role of imaging in suspected paediatric appendicitis: a scoping review

, 2023
Danielle Cadoret, Patricia Garcia, Amy Liscombe, Sean Flanagan   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings

, 2022
Anna S. Young, Nicholas J. Herkert, Heather M. Stapleton, Brent A. Coull, Russ Hauser, Thomas Zoeller, Peter Behnisch, Emiel Felzel, Abraham Brouwer, Joseph G. Allen   +9 more
openalex   +2 more sources

Correction to: Mesalazine formulation intolerance due to suspected excipient allergy in the treatment of ulcerative colitis: a case report [PDF]

, 2020
Yoshinori Arai, Maiko Ogawa, Fumitsugu Yamane, Natsuki Sumiyoshi, Rikako Arimoto, Yukio Ando, Daisuke Endo, T Nakada, I Sugawara, Hiroshi Yokoyama, Keiko Shimoyama, Hiroko Inomata, Yosuke Kawahara, Masayuki Kato, Seiji Arihiro, Atsushi Hokari, Masayuki Saruta   +16 more
openalex   +1 more source

Ken Arvidson - 1938-2011 [PDF]

, 2011
in memoriam - Kenneth Owen Arvidson was a local man and, one is driven to suspect, knew everyone and everything of the wider Waikato region. Born in Hamilton, Ken became a member of the English Department at Waikato University in 1974 where we were lucky
Pilditch, Jan
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Child abuse suspected with postmortem CT imaging and revealed by following legal autopsy

, 2010
Akihiro Suzuki, Masaya Sugimoto, Naohiro Kokita, Satoshi Fujita, Kazutomo Goh, Hiroshi Shiono, Keiko Shimizu   +6 more
openalex   +2 more sources