Results 181 to 190 of about 180,384 (297)

Environmental forensics in seawater coupling a divinylbenzene passive sampling device and high resolution mass spectrometry for the screening of micropollutants [PDF]

, 2017
Demeestere, Kristof, Huysman, Steve, Van Langenhove, Herman, Vanhaecke, Lynn, Vanryckeghem, Francis   +4 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of the composition of plant protection products in different formulation types employing suspect screening and unknown approaches. [PDF]

J Sci Food Agric, 2022
Hergueta-Castillo ME, López-Ruiz R, Garrido Frenich A, Romero-González R.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessment of the differentiation of Sambucus nigra plant parts using a multi-target and suspect screening by LC-HRMS and ICP-OES. [PDF]

Anal Bioanal Chem
Häßler M, Wetzel K, Warnecke L, Niedenthal T, Montero L, Ayala-Cabrera JF, Schmitz OJ.   +6 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches. [PDF]

Environ Sci Technol
Motteau S, Dervilly G, Cariou R, Margalef M, Lamoree M, Hamers T, König M, Escher BI, Vinggaard AM, Rørbye C, Le Bizec B, Antignac JP.   +11 more
europepmc   +1 more source

Suspect screening of wastewaters to trace anti-COVID-19 drugs: Potential adverse effects on aquatic environment. [PDF]

Sci Total Environ, 2022
Cappelli F, Longoni O, Rigato J, Rusconi M, Sala A, Fochi I, Palumbo MT, Polesello S, Roscioli C, Salerno F, Stefani F, Bettinetti R, Valsecchi S.   +12 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Supramolecular solvent-based all-in-one extractions for comprehensive suspect screening of chemicals in food contact materials. [PDF]

Mikrochim Acta
García-Cansino L, Caballero-Casero N, García MÁ, Marina ML, Rubio S.   +4 more
europepmc   +1 more source