Results 1 to 10 of about 18,265,067 (297)

Advances in Ultra-High-Resolution Mass Spectrometry for Pharmaceutical Analysis

Molecules, 2023
Pharmaceutical analysis refers to an area of analytical chemistry that deals with active compounds either by themselves (drug substance) or when formulated with excipients (drug product).
Estelle Deschamps, Valentina Calabrese, Isabelle Schmitz, Marie Hubert-Roux, Denis Castagnos, Carlos Afonso   +5 more
doaj   +3 more sources

Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Toxins, 2020
The increasing frequency of episodes of harmful algal blooms of cyanobacterial origin is a risk to ecosystems and human health. The main human hazard may arise from drinking water supply and recreational water use.
Daria Filatova, Oscar Núñez, Marinella Farré   +2 more
doaj   +3 more sources

Determination of Synthetic Cathinones in Urine and Oral Fluid by Liquid Chromatography High-Resolution Mass Spectrometry and Low-Resolution Mass Spectrometry: A Method Comparison

Separations, 2020
Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration ...
Sergi Pascual-Caro, Francesc Borrull, Carme Aguilar, Marta Calull   +3 more
doaj   +3 more sources

Proteogenomic analysis of Cyprinid herpesvirus 2 using high-resolution mass spectrometry [PDF]

Journal of Virology
Cyprinid herpesvirus 2 (CyHV-2) is the main pathogen responsible for the development of herpesviral hematopoietic necrosis disease (HVHND) in crucian carp (Carassius auratus). The CyHV-2 genome encodes approximately 150 genes that are expressed in a well-
Chen Xu, Fangxing Yu, Mingyang Xue, Zhenyu Huang, Nan Jiang, Yiqun Li, Yan Meng, Wenzhi Liu, Ya Zheng, Yuding Fan, Yong Zhou   +10 more
doaj   +2 more sources

The Development of New Methodology for Determination of Vincristine (VCR) in Human Serum Using LC-MS/MS-Based Method for Medical Diagnostics

Molecules, 2022
In this article, we have presented the development and validation of a rapid and sensitive reversed-phase liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for the determination of vincristine (VCR) in patient serum samples ...
Kamil Jurowski, Łukasz Paprotny, Marcin Zakrzewski, Dorota Wianowska, Joanna Kasprzyk-Pochopień, Małgorzata Herman, Katarzyna Madej, Wojciech Piekoszewski, Tomasz Kubrak   +8 more
doaj   +1 more source

Effects of excessive alcohol drinking on nicotine biotransformation in rats

Scientific Reports, 2022
Alcohol and nicotine (tobacco smoke) are often used together, and taking both addictive substances is associated with an increased risk of certain diseases. It is extremely important to understand the pharmacodynamic and pharmacokinetic mechanisms of the
Joanna Kasprzyk, Wojciech Piekoszewski, Artur Tezyk, Maksymilian Kulza, Ewa Florek   +4 more
doaj   +1 more source

Proteomic profiling of Serratia marcescens by high-resolution mass spectrometry [PDF]

BioImpacts, 2020
Introduction: Serratia marcescens, an opportunistic human pathogen, is reported as an important cause of nosocomial infection and outbreaks. Although the genome of S.
Bhavya Somalapura Gangadharappa, Sharath Rajashekarappa, Gajanan Sathe   +2 more
doaj   +1 more source

Evaluation of the Protective and Regenerative Properties of Commercially Available Artichoke Leaf Powder Extract on Plasma and Liver Oxidative Stress Parameters

Antioxidants, 2023
Hepatocellular damage by the harmful effects of xenobiotics, which increase the production of free radicals, is a widespread phenomenon. The extract from the leaves of Cynara scolymus L.
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelińska, Joanna Kasprzyk-Pochopień, Joanna Nawrot, Agnieszka Sobczak, Małgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak   +11 more
doaj   +1 more source

Acyl-Lipid Δ⁶-Desaturase May Act as a First FAD in Cyanobacteria

Biomolecules, 2022
Fatty acid desaturases (FADs) play important roles in various metabolic and adaptive pathways in all living organisms. They represent a superfamily of oxygenases that introduce double bonds into the acyl chains of fatty acids (FAs).
Alexander Y. Starikov, Roman A. Sidorov, Sergei V. Goriainov, Dmitry A. Los   +3 more
doaj   +1 more source

QuEChERS Method Combined with Gas- and Liquid-Chromatography High Resolution Mass Spectrometry to Screen and Confirm 237 Pesticides and Metabolites in Cottonseed Hull

Separations, 2022
Cottonseed hull is a livestock feed with large daily consumption. If pesticide residues exceed the standard, it is easy for them to be introduced into the human body through the food chain, with potential harm to consumer health.
Kaixuan Tong, Yujie Xie, Siqi Huang, Yongcheng Liu, Xingqiang Wu, Chunlin Fan, Hui Chen, Meiling Lu, Wenwen Wang   +8 more
doaj   +1 more source