Results 81 to 90 of about 180,384 (297)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sexual Assault Case Processing: A Descriptive Model of Attrition and Decision Making [PDF]

, 2006
The outcomes of sexual assaults involving one suspect and one victim reported to the Anchorage Police Department (APD) in 2000 to 2003 were examined.
Snodgrass, G. Matthew
core   +1 more source

Identification and characterization of tebuconazole transformation products in soil by combining suspect screening and molecular typology

, 2016
International audienceOnce released into the environment, pesticides generate transformation products (TPs) which may be of (eco-)toxicological importance.
Benoit, Pierre, Ferrari, Federico, Karas, Panagiotis, Karpouzas, Dimitrios, Lucini, Luigi, Mamy, Laure, Martin-Laurent, Fabrice, Nikolaki, Sofia, Papadopoulou, Evangelina, Servien, Rémi, Storck, Veronika, Trevisan, Marco   +11 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A study on neurodevelopmental outcome and its associated risk factors in very low birth weight babies in a tertiary care teaching hospital in Kolkata

Asian Journal of Medical Sciences, 2016
Background: Very low birth weight babies are very fragile in nature and usually undergone through stormy neonatal period, which affects significantly their neurodevelopmental outcome in long term basis. Aims and Objectives: 1.
Somen Sur
doaj   +1 more source

Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]

, 2014
Peer reviewedPublisher ...
Broenen, Emmi, Brüggemann, Roger, Kamphuis-van Ulzen, Karin, Mavinkurve-Groothuis, Annelies, Verweij, Paul, Warris, Adilia   +5 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers [PDF]

, 2009
Background. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.
Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti, Antonella Savarese, H Chaliki, RT Croyle, K Brain, C Lerman, KM Kash, M Watson, I Van Oostrom, AR Bradbury, G Rees, KJ Schlich-Bakker, K Kelly, KM Kelly, L D'Agincourt-Canning, MC Katapodi, MB Daly, FM Walter, JM Quillin, F Gil, A Caruso, DA Berry, G Parmigiani, M Federico, L Cortesi, A Caruso, A Caruso, C Lerman, D Ehus, DA Berry, TS Frank, FJ Couch, AS Zigmond, M Costantini, LG Bluman, J Cohen, JR Landis, C Foster, B Meiser, DG Evans, JT Heshka, C Condello, C Lerman   +47 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source