Results 61 to 70 of about 70,518 (290)
Overcoming Expert Disagreement In A Delphi Process. An Exercise In Reverse Epistemology [PDF]
, 2015 Disagreement among experts is a central topic in social epistemology. What should an expert do when confronted with the different opinion of an epistemic peer?
Elisabetta, Lalumera
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Contactless pellet fabrication [PDF]
, 1984 A small object is coated by holding it in the pressure well of an acoustic standing wave pattern, and then applying a mist of liquid coating material at low velocity into the pressure well.
Lee, M. C.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2019 A good account of the agnostic attitude of Suspending Judgement should explain how it can be rendered more or less rational/justified according to the state of one's evidence – and one's relation to that evidence.
Raleigh, Thomas
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Response Surface Methodology for Investigating the Effects of Hydrolysis Reaction Parameters on Molecular Structure and Performance of Polyvinyl Alcohol as Primary Suspending Agent [PDF]
Iranian Journal of Chemical Engineering, 2017 This study presents the synthesis of polyvinyl acetate (PVAc) by solution polymerization and its partial hydrolysis to polyvinyl alcohol (PVA) using alkaline alcoholysis. The influence of the molar ratio of hydrolysis catalyst (NaOH) to PVAc and the time
Z. Alihemati, A.H Navarchian
doaj
, 1977 A suspended mass is shaped by melting all or a selected portion of the mass and applying acoustic energy in varying amounts to different portions of the mass. In one technique for forming an optical waveguide slug, a mass of oval section is suspended and
Elleman, D. D., Wang, T. G.
core +1 more source
Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer. [PDF]
, 2014 BackgroundPancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to overcome this chemo-resistance have ...
Bold, Richard J +3 more
core +2 more sources
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source